Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1733225..1734861 Replicon chromosome
Accession NZ_CP099548
Organism Acinetobacter junii strain AJ6079

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NGM19_RS08090 Protein ID WP_075696499.1
Coordinates 1733225..1734556 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NGM19_RS08095 Protein ID WP_004954417.1
Coordinates 1734553..1734861 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGM19_RS08065 (NGM19_08065) 1728622..1729617 + 996 WP_075696503.1 DUF1852 domain-containing protein -
NGM19_RS08070 (NGM19_08070) 1729641..1730669 + 1029 WP_075696502.1 methionine synthase -
NGM19_RS08075 (NGM19_08075) 1730856..1731350 + 495 WP_004954405.1 flavin reductase -
NGM19_RS08080 (NGM19_08080) 1731392..1732189 + 798 WP_125318746.1 sulfite exporter TauE/SafE family protein -
NGM19_RS08085 (NGM19_08085) 1732249..1732947 - 699 WP_075696500.1 DUF1826 domain-containing protein -
NGM19_RS08090 (NGM19_08090) 1733225..1734556 + 1332 WP_075696499.1 HipA domain-containing protein Toxin
NGM19_RS08095 (NGM19_08095) 1734553..1734861 + 309 WP_004954417.1 helix-turn-helix transcriptional regulator Antitoxin
NGM19_RS08100 (NGM19_08100) 1734934..1735608 + 675 WP_004961827.1 HEPN domain-containing protein -
NGM19_RS08105 (NGM19_08105) 1735731..1735967 - 237 WP_004961824.1 VF530 family protein -
NGM19_RS08110 (NGM19_08110) 1736198..1737196 - 999 WP_252665572.1 AraC family transcriptional regulator -
NGM19_RS08115 (NGM19_08115) 1737320..1738018 + 699 WP_004915825.1 NAD(P)H-dependent oxidoreductase -
NGM19_RS08120 (NGM19_08120) 1738085..1738831 - 747 WP_151738530.1 iron-containing redox enzyme family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-365)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 50722.45 Da        Isoelectric Point: 5.0447

>T249107 WP_075696499.1 NZ_CP099548:1733225-1734556 [Acinetobacter junii]
MKKLTIQALLDQSWFDIAELTLLEPKLGSASASELAYELEYAIHNLDKQDEHACSLSLPVQILIKHESSSWFGFLDDIVP
SGAARRYWVNFLGLQRLTHAEQDSILLEKGGIAPVGNLRIKEALPPINPESTLHLRYFSQSDVADRNVDFLEYAQQMGAI
SGGATGAGGEAPKLLIRATKDQNIWIDTYQQNFDQPDQHYLVKFPRNNRSEIDCNILRAEYYYYQELKELGFNTIETTEM
KLIEGEKYPSLWLPRFDVEWHNQKWHRHGLESVYSVLNKASGSHLNHFEVIENLCNLLKSIDSEFDSEQFVCEWLQRDLL
NIIFGNSDNHGRNTSFLKQSGKISLAPIYDFAPMKADPEVVTRSITWGSPYEEGGEYRWEQITQKLAHLCDPNLSLTTLK
SLASHLVGLKQRLIDKGVPKQIMEMPALSFDYVEAKLERWELL

Download         Length: 1332 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11692.65 Da        Isoelectric Point: 9.9970

>AT249107 WP_004954417.1 NZ_CP099548:1734553-1734861 [Acinetobacter junii]
MNTKNQTQDRQQVLIDLYMQYLLNEITLGQLLAYLRKNILGMSQEQYANLVGVSRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVRKIIKPSE

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References