Detailed information of TA system TA024910

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 2490274..2490854
• Replicon: chromosome
• Accession: NC_014501
• Organism: Cyanothece sp. PCC 7822

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: E0UE86
• Locus tag: CYAN7822_RS10890
• Protein ID: WP_013322316.1
• Coordinates: 2490510..2490854 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: E0UE85
• Locus tag: CYAN7822_RS10885
• Protein ID: WP_013322315.1
• Coordinates: 2490274..2490516 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CYAN7822_RS37625	2485289..2485492	+	204	WP_157871802.1	hypothetical protein	-
CYAN7822_RS10855	2485499..2486713	+	1215	WP_013322309.1	YeeE/YedE family protein	-
CYAN7822_RS10860	2486723..2486872	-	150	WP_083786923.1	diguanylate cyclase	-
CYAN7822_RS10865	2487397..2487597	-	201	WP_013322310.1	hypothetical protein	-
CYAN7822_RS10870	2487799..2488440	+	642	WP_013322311.1	microcompartments protein	-
CYAN7822_RS10875	2488681..2489394	+	714	Protein_2189	hypothetical protein	-
CYAN7822_RS10880	2489587..2489802	-	216	WP_013322313.1	30S ribosomal protein S18	-
CYAN7822_RS35635	2489848..2490042	-	195	WP_013322314.1	50S ribosomal protein L33	-
CYAN7822_RS10885	2490274..2490516	+	243	WP_013322315.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
CYAN7822_RS10890	2490510..2490854	+	345	WP_013322316.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
CYAN7822_RS10895	2490924..2493155	-	2232	WP_013322317.1	FAD/NAD(P)-binding protein	-
CYAN7822_RS10900	2493374..2494645	-	1272	WP_013322318.1	family 10 glycosylhydrolase	-
CYAN7822_RS10905	2494729..2495157	-	429	WP_013322319.1	Holliday junction resolvase RuvX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-112)

Antitoxin

• SpoVT-AbrB domain (8-50)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 12622.79 Da
• Isoelectric Point: 8.1175

>T24910 WP_013322316.1 NC_014501:2490510-2490854 [Gloeothece verrucosa PCC 7822]
MVKIDGSIPCRGDIIRLSLNPRTGSEQSGIRPALVISPQAYNRVSKIILICPITSKEKGWPFEVKLPDSCQVQGVVLVDQ
LRAVDCQARNANFIEKISMETLNEIMARLESLVT

Nucleotide

• Length: 345 bp

>T24910 NC_014501:2490510-2490854 [Gloeothece verrucosa PCC 7822]
TTGGTAAAAATTGATGGTAGTATTCCCTGTCGTGGCGATATCATCAGGCTTTCATTAAATCCGCGAACCGGCAGTGAACA
ATCTGGGATACGTCCGGCCTTAGTGATTTCTCCCCAAGCCTATAATCGAGTCTCAAAAATTATTTTAATCTGCCCCATTA
CGAGCAAGGAAAAGGGGTGGCCTTTTGAAGTGAAATTGCCGGATTCGTGCCAGGTTCAAGGAGTAGTATTGGTCGATCAA
TTAAGAGCCGTCGATTGTCAAGCTAGAAATGCTAACTTTATCGAAAAAATCTCGATGGAAACGTTAAACGAAATCATGGC
TCGTCTTGAATCTTTGGTAACATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9134.33 Da
• Isoelectric Point: 4.2103

>AT24910 WP_013322315.1 NC_014501:2490274-2490516 [Gloeothece verrucosa PCC 7822]
MVIQKLSQWGNSLGIRLPQAIIQEIGLNEGDLLRISLENNRIILSPARPKYTLSELLQNISADQQHEEIEWGDPQGDEIW

Nucleotide

• Length: 243 bp

>AT24910 NC_014501:2490274-2490516 [Gloeothece verrucosa PCC 7822]
ATGGTGATACAAAAGTTAAGTCAGTGGGGTAACTCTCTTGGGATAAGACTACCACAGGCGATAATTCAAGAAATTGGGCT
AAATGAAGGAGATTTATTAAGGATTTCCTTAGAAAATAATCGAATTATTTTATCACCTGCCCGTCCTAAATACACCCTCT
CCGAATTACTTCAAAATATCTCTGCCGATCAACAGCATGAAGAAATCGAGTGGGGCGATCCCCAAGGAGACGAGATTTGG
TAA

Structures

Toxin

• AlphaFold DB: E0UE86

Antitoxin

• AlphaFold DB: E0UE85