Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 212531..213051 Replicon plasmid unnamed
Accession NZ_CP099541
Organism Pantoea stewartii strain HR3-48

Toxin (Protein)


Gene name ccdB Uniprot ID H3RK38
Locus tag NG832_RS21575 Protein ID WP_006121898.1
Coordinates 212752..213051 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H3RK39
Locus tag NG832_RS21570 Protein ID WP_006121899.1
Coordinates 212531..212749 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NG832_RS21545 (NG832_21485) 208677..209576 + 900 WP_185200244.1 hypothetical protein -
NG832_RS21550 (NG832_21490) 209585..210793 + 1209 WP_263759584.1 response regulator -
NG832_RS21555 (NG832_21495) 210790..211128 + 339 WP_033742520.1 STAS domain-containing protein -
NG832_RS21560 (NG832_21500) 211130..211555 + 426 WP_263759587.1 ATP-binding protein -
NG832_RS21565 (NG832_21505) 211758..212018 - 261 WP_054633991.1 hypothetical protein -
NG832_RS21570 (NG832_21510) 212531..212749 + 219 WP_006121899.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
NG832_RS21575 (NG832_21515) 212752..213051 + 300 WP_006121898.1 CcdB family protein Toxin
NG832_RS21580 (NG832_21520) 213220..213915 - 696 WP_054633989.1 ROK family protein -
NG832_RS21585 (NG832_21525) 213933..215303 - 1371 WP_054633988.1 glucose-6-phosphate dehydrogenase -
NG832_RS21590 (NG832_21530) 215321..216325 - 1005 WP_039339386.1 decarboxylating 6-phosphogluconate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul1 / qacE / aadA2 fliC 1..333832 333832


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-98)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 10974.67 Da        Isoelectric Point: 7.0045

>T249096 WP_006121898.1 NZ_CP099541:212752-213051 [Pantoea stewartii]
MQFDVYSHKNGKKYPYLVEVQSYLIDTPGRLMVAPLALPGEFVGSGELYPEVLVNGSKYRVVTTDIASVPVKALGDKVGD
VSQYEAAIKNAIFRLFWGF

Download         Length: 300 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8516.56 Da        Isoelectric Point: 5.1504

>AT249096 WP_006121899.1 NZ_CP099541:212531-212749 [Pantoea stewartii]
MKYRTNVTIDKEAYEIFSSAGLNLSKMVNELVTTEARRIRAERWKEENRESMKAFSDFVGEEGSLSDMYRNW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H3RK38

Antitoxin

Source ID Structure
AlphaFold DB H3RK39

References