249093

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2690872..2691489 Replicon chromosome
Accession NZ_CP099535
Organism Pantoea ananatis strain JT1-188

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag NG826_RS12745 Protein ID WP_028723979.1
Coordinates 2691274..2691489 (+) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag NG826_RS12740 Protein ID WP_028723978.1
Coordinates 2690872..2691249 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NG826_RS12710 (NG826_12670) 2687158..2687412 + 255 WP_014606427.1 type B 50S ribosomal protein L31 -
NG826_RS12715 (NG826_12675) 2687424..2687564 + 141 WP_014606428.1 type B 50S ribosomal protein L36 -
NG826_RS12720 (NG826_12680) 2687624..2688502 - 879 WP_028723975.1 metal ABC transporter substrate-binding protein -
NG826_RS12725 (NG826_12685) 2688515..2689354 - 840 WP_013024907.1 metal ABC transporter permease -
NG826_RS12730 (NG826_12690) 2689351..2690019 - 669 WP_263793366.1 ABC transporter ATP-binding protein -
NG826_RS12735 (NG826_12695) 2690372..2690725 + 354 WP_028723977.1 hypothetical protein -
NG826_RS12740 (NG826_12700) 2690872..2691249 + 378 WP_028723978.1 Hha toxicity modulator TomB Antitoxin
NG826_RS12745 (NG826_12705) 2691274..2691489 + 216 WP_028723979.1 HHA domain-containing protein Toxin
NG826_RS12755 (NG826_12715) 2691887..2692198 + 312 WP_263793367.1 MGMT family protein -
NG826_RS12760 (NG826_12720) 2692247..2692804 - 558 WP_013024901.1 YbaY family lipoprotein -
NG826_RS12765 (NG826_12725) 2692997..2693860 + 864 WP_064365625.1 acyl-CoA thioesterase II -
NG826_RS12770 (NG826_12730) 2693907..2695196 - 1290 WP_028723982.1 ammonium transporter AmtB -
NG826_RS12775 (NG826_12735) 2695231..2695569 - 339 WP_013024898.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8542.94 Da        Isoelectric Point: 9.4825

>T249093 WP_028723979.1 NZ_CP099535:2691274-2691489 [Pantoea ananatis]
MNKTLTKTDYLMRLRRCRSIDTLERVIEKNKYELSDEELAVFYSAADHRLAELTMNKLYDKVPVSVWKFVR

Download         Length: 216 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14709.35 Da        Isoelectric Point: 4.4069

>AT249093 WP_028723978.1 NZ_CP099535:2690872-2691249 [Pantoea ananatis]
MDEYSPKRHDIAQLKYLCESLFDESMATLTDSHHGWVNDPTAESNLQLNDLIEHIASFTMNYKIKHVEDEALITQIDEYL
DDTFMLFSNYSVNTQDLQRWQRSAKRLFNVFTEECAFLQQPSHSL

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References