Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4856543..4858128 Replicon chromosome
Accession NC_014500
Organism Dickeya dadantii 3937

Toxin (Protein)


Gene name hipA Uniprot ID E0SNG2
Locus tag DDA3937_RS21315 Protein ID WP_013320105.1
Coordinates 4856543..4857862 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag DDA3937_RS21320 Protein ID WP_033112453.1
Coordinates 4857862..4858128 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DDA3937_RS22555 (Dda3937_04716) 4852618..4852758 + 141 WP_004093983.1 50S ribosomal protein L34 -
DDA3937_RS21300 (Dda3937_01061) 4852777..4853136 + 360 WP_013320101.1 ribonuclease P protein component -
DDA3937_RS22560 (Dda3937_01062) 4853100..4853357 + 258 WP_013320102.1 membrane protein insertion efficiency factor YidD -
DDA3937_RS21305 (Dda3937_01063) 4853360..4854991 + 1632 WP_013320103.1 membrane protein insertase YidC -
DDA3937_RS21310 (Dda3937_01064) 4855107..4856471 + 1365 WP_013320104.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
DDA3937_RS21315 (Dda3937_01065) 4856543..4857862 - 1320 WP_013320105.1 type II toxin-antitoxin system HipA family toxin Toxin
DDA3937_RS21320 (Dda3937_01066) 4857862..4858128 - 267 WP_033112453.1 helix-turn-helix domain-containing protein Antitoxin
DDA3937_RS21325 (Dda3937_01067) 4858378..4859355 - 978 WP_013320107.1 helix-turn-helix domain-containing protein -
DDA3937_RS21330 (Dda3937_01068) 4859398..4860171 - 774 WP_033112166.1 MBL fold metallo-hydrolase -
DDA3937_RS21335 (Dda3937_01069) 4860486..4861571 + 1086 WP_033112167.1 4-hydroxyphenylpyruvate dioxygenase -
DDA3937_RS21340 (Dda3937_01070) 4861696..4862076 - 381 WP_033112454.1 helix-turn-helix transcriptional regulator -
DDA3937_RS21345 (Dda3937_01071) 4862219..4862830 + 612 WP_013320111.1 NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49355.47 Da        Isoelectric Point: 7.3308

>T24909 WP_013320105.1 NC_014500:c4857862-4856543 [Dickeya dadantii 3937]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLGLPGNRPISLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVARHH
ADSTQPFDLLAKVGQDSVGALQLVPQGIPARDIKQIEYKTLSEQQLESILSGYLSDAPLGMIDTEDDFRISIAGAQEKTA
LLYLDNHWCLPFNTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIARAFGLPVPHCFMIKAGKIKALAVERFDRK
YASDGSWIMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSYLLGAVDPQRDRYSFMKAQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPAFGGRGIDRRDAKLAMGLAGTRGKKYHIEQIFPRHFFQTAKAVGFARESMERILTEFSQTV
DSVIVSVRNQLPADFPTPIRDAILGGLQTRSRRLTTGWE

Download         Length: 1320 bp

>T24909 NC_014500:c4857862-4856543 [Dickeya dadantii 3937]
ATGGCTGCGCTCGATGTTTACATGAACGGCTACCGGGTGGGGATTCTGACCAAAACGGGCAGTGGCGCACATCATTTTTC
CTACGATGCGAACTGGCTCGGGTTGCCGGGGAACCGACCCATTTCGCTCTCTATGCCACTACGCCATCAGCCCTATCAAG
GTGATGAAGTTTATAATTTCTTCGACAATTTGTTGCCGGATAACCCGGATATCAGAAGGCGAATTGTTGCCAGGCATCAT
GCGGATTCCACCCAGCCGTTTGATCTGCTGGCTAAAGTGGGGCAAGACAGTGTCGGGGCGTTGCAATTGGTGCCGCAGGG
TATTCCTGCTCGCGATATAAAACAGATTGAATATAAAACATTATCCGAGCAACAGCTTGAAAGCATACTGTCGGGGTATC
TGTCCGATGCCCCTCTGGGGATGATTGATACAGAAGACGATTTTCGAATCTCTATTGCTGGCGCACAGGAAAAAACGGCC
CTGCTTTATCTGGATAATCACTGGTGCCTGCCCTTCAATACCACACCAACTACCCACATCATCAAGCTACCGATTGGTAA
AATCGAGAGTCATTCTTACTCAATTGATATGTCTGACAGCGTTGAAAATGAGTACCTGTGCCTGCTCATTGCCAGGGCAT
TTGGGCTACCGGTGCCGCACTGTTTTATGATCAAAGCTGGCAAGATAAAAGCGCTGGCCGTTGAGCGTTTTGATCGCAAA
TATGCTTCGGATGGCAGTTGGATTATGCGGCTGCCGCAGGAGGATTTTTGTCAGGTATTAAACGTGCCTTCCGCACTAAA
ATATGAAAATCATGGTGGACCAGGTATTTCCGCCATTATGTCGTATCTATTAGGCGCGGTTGATCCACAAAGGGATCGTT
ATAGTTTTATGAAGGCGCAGGTGCTGTTTTGGTTATTGGCTGCAACGGATGGGCATGCAAAAAACTTCTCCCTGTTTATT
GAGTCTGAGGGACGATATCGCCTCACGCCTTTCTATGACATTCTCTCTATGTACCCGGCATTTGGCGGCCGGGGAATTGA
CCGTAGAGATGCGAAGCTAGCGATGGGGCTGGCTGGCACCAGAGGTAAGAAATACCATATCGAGCAGATATTCCCTCGGC
ATTTTTTCCAAACGGCAAAGGCGGTTGGCTTTGCCAGAGAATCAATGGAACGCATTCTGACTGAATTTTCACAGACGGTT
GATTCTGTCATCGTGAGTGTCAGAAACCAACTGCCTGCGGATTTTCCCACTCCTATTCGCGATGCGATCCTGGGAGGGCT
ACAGACTAGATCGAGGCGATTGACGACGGGTTGGGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9883.23 Da        Isoelectric Point: 9.7281

>AT24909 WP_033112453.1 NC_014500:c4858128-4857862 [Dickeya dadantii 3937]
MKVTNAKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNMDAANNEASV
APSWKEEW

Download         Length: 267 bp

>AT24909 NC_014500:c4858128-4857862 [Dickeya dadantii 3937]
ATGAAAGTCACCAACGCCAAACAGCTTAGCAGCTATCTGAAAGATGTTCGTATCACGCAGAAGCTTTCACAAGGGAAAGT
GGCCAGTAAAGTGGGTATTCGCCAGGACACGGTATCCAGCTTCGAACAACATCCTGATTCCACCAAGCTGGAAACATTCT
TTAAAATCCTGTCGGCATTAAATTTAGAACTTACGGTTACTCCCAGGAATATGGATGCCGCCAATAACGAGGCCTCTGTC
GCACCATCCTGGAAGGAAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E0SNG2

Antitoxin

Source ID Structure

References