Detailed information of TA system TA024909

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4856543..4858128
• Replicon: chromosome
• Accession: NC_014500
• Organism: Dickeya dadantii 3937

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: E0SNG2
• Locus tag: DDA3937_RS21315
• Protein ID: WP_013320105.1
• Coordinates: 4856543..4857862 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: DDA3937_RS21320
• Protein ID: WP_033112453.1
• Coordinates: 4857862..4858128 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49355.47 Da
• Isoelectric Point: 7.3308

>T24909 WP_013320105.1 NC_014500:c4857862-4856543 [Dickeya dadantii 3937]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLGLPGNRPISLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVARHH
ADSTQPFDLLAKVGQDSVGALQLVPQGIPARDIKQIEYKTLSEQQLESILSGYLSDAPLGMIDTEDDFRISIAGAQEKTA
LLYLDNHWCLPFNTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIARAFGLPVPHCFMIKAGKIKALAVERFDRK
YASDGSWIMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSYLLGAVDPQRDRYSFMKAQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPAFGGRGIDRRDAKLAMGLAGTRGKKYHIEQIFPRHFFQTAKAVGFARESMERILTEFSQTV
DSVIVSVRNQLPADFPTPIRDAILGGLQTRSRRLTTGWE

Nucleotide

• Length: 1320 bp

>T24909 NC_014500:c4857862-4856543 [Dickeya dadantii 3937]
ATGGCTGCGCTCGATGTTTACATGAACGGCTACCGGGTGGGGATTCTGACCAAAACGGGCAGTGGCGCACATCATTTTTC
CTACGATGCGAACTGGCTCGGGTTGCCGGGGAACCGACCCATTTCGCTCTCTATGCCACTACGCCATCAGCCCTATCAAG
GTGATGAAGTTTATAATTTCTTCGACAATTTGTTGCCGGATAACCCGGATATCAGAAGGCGAATTGTTGCCAGGCATCAT
GCGGATTCCACCCAGCCGTTTGATCTGCTGGCTAAAGTGGGGCAAGACAGTGTCGGGGCGTTGCAATTGGTGCCGCAGGG
TATTCCTGCTCGCGATATAAAACAGATTGAATATAAAACATTATCCGAGCAACAGCTTGAAAGCATACTGTCGGGGTATC
TGTCCGATGCCCCTCTGGGGATGATTGATACAGAAGACGATTTTCGAATCTCTATTGCTGGCGCACAGGAAAAAACGGCC
CTGCTTTATCTGGATAATCACTGGTGCCTGCCCTTCAATACCACACCAACTACCCACATCATCAAGCTACCGATTGGTAA
AATCGAGAGTCATTCTTACTCAATTGATATGTCTGACAGCGTTGAAAATGAGTACCTGTGCCTGCTCATTGCCAGGGCAT
TTGGGCTACCGGTGCCGCACTGTTTTATGATCAAAGCTGGCAAGATAAAAGCGCTGGCCGTTGAGCGTTTTGATCGCAAA
TATGCTTCGGATGGCAGTTGGATTATGCGGCTGCCGCAGGAGGATTTTTGTCAGGTATTAAACGTGCCTTCCGCACTAAA
ATATGAAAATCATGGTGGACCAGGTATTTCCGCCATTATGTCGTATCTATTAGGCGCGGTTGATCCACAAAGGGATCGTT
ATAGTTTTATGAAGGCGCAGGTGCTGTTTTGGTTATTGGCTGCAACGGATGGGCATGCAAAAAACTTCTCCCTGTTTATT
GAGTCTGAGGGACGATATCGCCTCACGCCTTTCTATGACATTCTCTCTATGTACCCGGCATTTGGCGGCCGGGGAATTGA
CCGTAGAGATGCGAAGCTAGCGATGGGGCTGGCTGGCACCAGAGGTAAGAAATACCATATCGAGCAGATATTCCCTCGGC
ATTTTTTCCAAACGGCAAAGGCGGTTGGCTTTGCCAGAGAATCAATGGAACGCATTCTGACTGAATTTTCACAGACGGTT
GATTCTGTCATCGTGAGTGTCAGAAACCAACTGCCTGCGGATTTTCCCACTCCTATTCGCGATGCGATCCTGGGAGGGCT
ACAGACTAGATCGAGGCGATTGACGACGGGTTGGGAATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9883.23 Da
• Isoelectric Point: 9.7281

>AT24909 WP_033112453.1 NC_014500:c4858128-4857862 [Dickeya dadantii 3937]
MKVTNAKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNMDAANNEASV
APSWKEEW

Nucleotide

• Length: 267 bp

>AT24909 NC_014500:c4858128-4857862 [Dickeya dadantii 3937]
ATGAAAGTCACCAACGCCAAACAGCTTAGCAGCTATCTGAAAGATGTTCGTATCACGCAGAAGCTTTCACAAGGGAAAGT
GGCCAGTAAAGTGGGTATTCGCCAGGACACGGTATCCAGCTTCGAACAACATCCTGATTCCACCAAGCTGGAAACATTCT
TTAAAATCCTGTCGGCATTAAATTTAGAACTTACGGTTACTCCCAGGAATATGGATGCCGCCAATAACGAGGCCTCTGTC
GCACCATCCTGGAAGGAAGAATGGTAA

Structures

Toxin

• AlphaFold DB: E0SNG2