Detailed information of TA system TA249080

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 3790282..3790787
• Replicon: chromosome
• Accession: NZ_CP099531
• Organism: Xanthomonas sacchari strain HR3-46

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: NG825_RS15965
• Protein ID: WP_284467684.1
• Coordinates: 3790530..3790787 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relE
• Uniprot ID: A0A6N7Q778
• Locus tag: NG825_RS15960
• Protein ID: WP_017907919.1
• Coordinates: 3790282..3790533 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NG825_RS15945 (NG825_15910)	3785463..3788675	+	3213	WP_284467681.1	error-prone DNA polymerase	-
NG825_RS15950 (NG825_15915)	3788825..3789136	-	312	WP_284467682.1	hypothetical protein	-
NG825_RS15955 (NG825_15920)	3789370..3790119	-	750	WP_284467683.1	endonuclease	-
NG825_RS15960 (NG825_15925)	3790282..3790533	+	252	WP_017907919.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
NG825_RS15965 (NG825_15930)	3790530..3790787	+	258	WP_284467684.1	Txe/YoeB family addiction module toxin	Toxin
NG825_RS15970 (NG825_15935)	3790836..3791558	-	723	WP_152243104.1	hypothetical protein	-
NG825_RS15980 (NG825_15945)	3791971..3792324	-	354	WP_010342469.1	PilZ domain-containing protein	-
NG825_RS15985 (NG825_15950)	3792321..3793283	-	963	WP_284467685.1	DNA polymerase III subunit delta'	-
NG825_RS15990 (NG825_15955)	3793280..3793951	-	672	WP_017917512.1	dTMP kinase	-
NG825_RS15995 (NG825_15960)	3793948..3795009	-	1062	WP_284467686.1	endolytic transglycosylase MltG	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10189.73 Da
• Isoelectric Point: 9.6589

>T249080 WP_284467684.1 NZ_CP099531:3790530-3790787 [Xanthomonas sacchari]
VTLQFSDNAWEDYLYWQQADKKMLKRINDLIKAIQRDPLQGIGKPEPLRHALAGYWSRRVNDEHRIVYKVEHGVLLIAQL
RYHYV

Nucleotide

• Length: 258 bp

>T249080 NZ_CP099531:3790530-3790787 [Xanthomonas sacchari]
GTGACGCTGCAGTTCTCGGACAACGCCTGGGAGGATTATCTCTACTGGCAACAGGCCGACAAAAAGATGCTCAAGCGCAT
CAACGACCTGATCAAGGCCATTCAACGCGATCCCTTGCAGGGCATCGGCAAACCCGAACCGCTACGCCATGCCCTGGCCG
GCTATTGGTCGCGACGCGTCAACGACGAACACCGGATCGTCTATAAGGTCGAGCATGGCGTCCTGTTGATTGCACAACTG
CGGTATCACTACGTGTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9324.59 Da
• Isoelectric Point: 5.1186

>AT249080 WP_017907919.1 NZ_CP099531:3790282-3790533 [Xanthomonas sacchari]
MDTITYSAARAALADTMDRVVNNHEPVIITRSREQAVVMLSLEDYKAMEETAYLLRSPKNAQRLLESIAQLESGRGKARE
LSE

Nucleotide

• Length: 252 bp

>AT249080 NZ_CP099531:3790282-3790533 [Xanthomonas sacchari]
ATGGACACCATCACCTACAGCGCCGCACGTGCCGCTCTCGCGGACACCATGGACCGCGTGGTCAACAACCACGAGCCGGT
GATCATTACGCGCAGCCGCGAGCAAGCCGTCGTCATGCTGTCGCTGGAGGACTACAAGGCGATGGAAGAAACCGCTTATT
TGCTGCGTAGCCCGAAGAACGCGCAGCGCCTGCTGGAATCCATCGCACAACTCGAATCCGGTCGCGGCAAGGCGCGGGAA
CTGAGCGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A6N7Q778