Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 1768..2348 Replicon plasmid pSZS128-ccl
Accession NZ_CP099525
Organism Klebsiella pneumoniae strain SZS128

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag NG894_RS28420 Protein ID WP_071177730.1
Coordinates 2034..2348 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag NG894_RS28415 Protein ID WP_000093040.1
Coordinates 1768..2046 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NG894_RS28400 (NG894_28380) 341..586 + 246 WP_032440458.1 hypothetical protein -
NG894_RS28405 (NG894_28385) 860..1231 + 372 WP_001237044.1 cell envelope integrity protein TolA -
NG894_RS28410 (NG894_28390) 1228..1593 + 366 WP_072354022.1 TonB family protein -
NG894_RS28415 (NG894_28395) 1768..2046 + 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
NG894_RS28420 (NG894_28400) 2034..2348 + 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NG894_RS28425 (NG894_28405) 2512..2940 + 429 WP_001140599.1 hypothetical protein -
NG894_RS28430 (NG894_28410) 2966..3145 + 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
NG894_RS28435 (NG894_28415) 3172..3702 - 531 WP_071177729.1 hypothetical protein -
NG894_RS28440 (NG894_28420) 3709..4440 - 732 WP_071177728.1 MobC family replication-relaxation protein -
NG894_RS28445 (NG894_28425) 4440..6404 - 1965 WP_071177727.1 TraM recognition domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10060 10060


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T249076 WP_071177730.1 NZ_CP099525:2034-2348 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT249076 WP_000093040.1 NZ_CP099525:1768-2046 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References