249073

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 222574..223096 Replicon plasmid pSZS128-Hv-MDR
Accession NZ_CP099523
Organism Klebsiella pneumoniae strain SZS128

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag NG894_RS27655 Protein ID WP_004181778.1
Coordinates 222812..223096 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag NG894_RS27650 Protein ID WP_004181777.1
Coordinates 222574..222822 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NG894_RS27630 (NG894_27615) 217783..218604 - 822 WP_004181772.1 hypothetical protein -
NG894_RS27635 (NG894_27620) 218666..219019 - 354 WP_004181774.1 hypothetical protein -
NG894_RS27640 (NG894_27625) 219164..220150 - 987 WP_101992392.1 hypothetical protein -
NG894_RS27645 (NG894_27630) 220484..222283 - 1800 WP_004181776.1 ATP-dependent helicase -
NG894_RS27650 (NG894_27635) 222574..222822 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NG894_RS27655 (NG894_27640) 222812..223096 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NG894_RS27660 (NG894_27645) 223113..223214 - 102 Protein_241 IS200/IS605 family transposase -
NG894_RS27665 (NG894_27650) 223250..224476 + 1227 WP_040209639.1 RNA-guided endonuclease TnpB family protein -
NG894_RS27670 (NG894_27655) 224747..224971 - 225 Protein_243 transposase -
NG894_RS27675 (NG894_27660) 225050..225478 - 429 WP_077257669.1 IS200/IS605 family transposase -
NG894_RS27680 (NG894_27665) 225514..226701 + 1188 WP_040209642.1 RNA-guided endonuclease TnpB family protein -
NG894_RS27685 (NG894_27670) 226746..227117 - 372 WP_040209644.1 hypothetical protein -
NG894_RS27690 (NG894_27675) 227114..227458 - 345 WP_228306996.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B / aac(3)-IId / blaSHV-12 / qnrB4 / blaDHA-1 / sul1 / armA / msr(E) / mph(E) / mph(A) rmpA / iutA / iucD / iucC / iucB / iucA 1..302470 302470


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T249073 WP_004181778.1 NZ_CP099523:222812-223096 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT249073 WP_004181777.1 NZ_CP099523:222574-222822 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References