249072

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 185883..186409 Replicon plasmid pSZS128-Hv-MDR
Accession NZ_CP099523
Organism Klebsiella pneumoniae strain SZS128

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag NG894_RS27450 Protein ID WP_000323025.1
Coordinates 185883..186170 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag NG894_RS27455 Protein ID WP_000534858.1
Coordinates 186170..186409 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NG894_RS27420 (NG894_27405) 180929..181162 - 234 WP_004181905.1 hypothetical protein -
NG894_RS27425 (NG894_27410) 181241..181588 - 348 WP_004181904.1 hypothetical protein -
NG894_RS27430 (NG894_27415) 181744..182811 - 1068 WP_004181903.1 hypothetical protein -
NG894_RS27435 (NG894_27420) 183501..183878 + 378 WP_004181901.1 hypothetical protein -
NG894_RS27440 (NG894_27425) 184076..185050 - 975 WP_004181899.1 hypothetical protein -
NG894_RS27445 (NG894_27430) 185653..185811 - 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
NG894_RS27450 (NG894_27435) 185883..186170 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
NG894_RS27455 (NG894_27440) 186170..186409 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
NG894_RS27460 (NG894_27445) 186434..186538 + 105 Protein_201 hypothetical protein -
NG894_RS27465 (NG894_27450) 186672..187088 - 417 Protein_202 cation-efflux pump -
NG894_RS27470 (NG894_27455) 187161..188329 + 1169 WP_085929673.1 IS3-like element ISEc52 family transposase -
NG894_RS27475 (NG894_27460) 188339..188650 - 312 Protein_204 IS110 family transposase -
NG894_RS27480 (NG894_27465) 189071..190411 - 1341 WP_000589001.1 ISNCY family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B / aac(3)-IId / blaSHV-12 / qnrB4 / blaDHA-1 / sul1 / armA / msr(E) / mph(E) / mph(A) rmpA / iutA / iucD / iucC / iucB / iucA 1..302470 302470


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T249072 WP_000323025.1 NZ_CP099523:c186170-185883 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT249072 WP_000534858.1 NZ_CP099523:c186409-186170 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References