Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 8686..9596 | Replicon | plasmid pSZS128-Hv-MDR |
| Accession | NZ_CP099523 | ||
| Organism | Klebsiella pneumoniae strain SZS128 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A663AYG0 |
| Locus tag | NG894_RS26495 | Protein ID | WP_004026354.1 |
| Coordinates | 9126..9596 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J4RLY9 |
| Locus tag | NG894_RS26490 | Protein ID | WP_004181895.1 |
| Coordinates | 8686..9129 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NG894_RS26465 (NG894_26450) | 3723..3929 | + | 207 | WP_004026437.1 | hypothetical protein | - |
| NG894_RS26470 (NG894_26455) | 4013..4492 | + | 480 | WP_004181843.1 | hypothetical protein | - |
| NG894_RS26475 (NG894_26460) | 5319..6806 | + | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
| NG894_RS26480 (NG894_26465) | 6892..7314 | + | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| NG894_RS26485 (NG894_26470) | 7314..8585 | + | 1272 | WP_152900732.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| NG894_RS26490 (NG894_26475) | 8686..9129 | + | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
| NG894_RS26495 (NG894_26480) | 9126..9596 | + | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
| NG894_RS26500 (NG894_26485) | 9706..9966 | - | 261 | WP_004026352.1 | hypothetical protein | - |
| NG894_RS26505 (NG894_26490) | 10537..11718 | - | 1182 | WP_078207741.1 | IS481 family transposase | - |
| NG894_RS26510 (NG894_26495) | 11819..12523 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| NG894_RS26515 (NG894_26500) | 12588..13838 | - | 1251 | Protein_12 | transposase | - |
| NG894_RS26520 (NG894_26505) | 13913..14581 | - | 669 | WP_001300294.1 | EAL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaTEM-1B / aac(3)-IId / blaSHV-12 / qnrB4 / blaDHA-1 / sul1 / armA / msr(E) / mph(E) / mph(A) | rmpA / iutA / iucD / iucC / iucB / iucA | 1..302470 | 302470 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T249070 WP_004026354.1 NZ_CP099523:9126-9596 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT249070 WP_004181895.1 NZ_CP099523:8686-9129 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AYG0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4RLY9 |