249067

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4824813..4825329 Replicon chromosome
Accession NZ_CP099522
Organism Klebsiella pneumoniae strain SZS128

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag NG894_RS23855 Protein ID WP_002886902.1
Coordinates 4824813..4825097 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NG894_RS23860 Protein ID WP_002886901.1
Coordinates 4825087..4825329 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NG894_RS23830 (NG894_23815) 4820297..4820560 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
NG894_RS23835 (NG894_23820) 4820690..4820863 + 174 WP_002886906.1 hypothetical protein -
NG894_RS23840 (NG894_23825) 4820866..4821609 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NG894_RS23845 (NG894_23830) 4821966..4824104 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
NG894_RS23850 (NG894_23835) 4824345..4824809 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NG894_RS23855 (NG894_23840) 4824813..4825097 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NG894_RS23860 (NG894_23845) 4825087..4825329 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NG894_RS23865 (NG894_23850) 4825407..4827317 - 1911 WP_004152270.1 PRD domain-containing protein -
NG894_RS23870 (NG894_23855) 4827340..4828494 - 1155 WP_002886900.1 lactonase family protein -
NG894_RS23875 (NG894_23860) 4828560..4829300 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T249067 WP_002886902.1 NZ_CP099522:c4825097-4824813 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT249067 WP_002886901.1 NZ_CP099522:c4825329-4825087 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References