Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 2693193..2694781 | Replicon | chromosome |
Accession | NZ_CP099522 | ||
Organism | Klebsiella pneumoniae strain SZS128 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | A0A0H3GN97 |
Locus tag | NG894_RS13385 | Protein ID | WP_004199851.1 |
Coordinates | 2693193..2694515 (-) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | A0A0H3GXD8 |
Locus tag | NG894_RS13390 | Protein ID | WP_002904790.1 |
Coordinates | 2694515..2694781 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NG894_RS13370 (NG894_13360) | 2688258..2690759 | + | 2502 | WP_004199853.1 | fimbria/pilus outer membrane usher protein | - |
NG894_RS13375 (NG894_13365) | 2690747..2691751 | + | 1005 | WP_004199852.1 | fimbrial protein | - |
NG894_RS13380 (NG894_13370) | 2691884..2693176 | + | 1293 | WP_002904794.1 | glycoside hydrolase family 10 protein | - |
NG894_RS13385 (NG894_13375) | 2693193..2694515 | - | 1323 | WP_004199851.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
NG894_RS13390 (NG894_13380) | 2694515..2694781 | - | 267 | WP_002904790.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
NG894_RS13395 (NG894_13385) | 2695047..2695373 | - | 327 | WP_002904788.1 | hydroxyisourate hydrolase | - |
NG894_RS13400 (NG894_13390) | 2695370..2695870 | - | 501 | WP_002904787.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
NG894_RS13405 (NG894_13395) | 2695848..2697227 | - | 1380 | WP_004199850.1 | nucleobase:cation symporter-2 family protein | - |
NG894_RS13410 (NG894_13400) | 2697573..2698727 | + | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
NG894_RS13415 (NG894_13405) | 2698708..2699631 | - | 924 | WP_004199849.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49128.44 Da Isoelectric Point: 7.2487
>T249064 WP_004199851.1 NZ_CP099522:c2694515-2693193 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GN97 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GXD8 |