Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2693193..2694781 Replicon chromosome
Accession NZ_CP099522
Organism Klebsiella pneumoniae strain SZS128

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag NG894_RS13385 Protein ID WP_004199851.1
Coordinates 2693193..2694515 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NG894_RS13390 Protein ID WP_002904790.1
Coordinates 2694515..2694781 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NG894_RS13370 (NG894_13360) 2688258..2690759 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
NG894_RS13375 (NG894_13365) 2690747..2691751 + 1005 WP_004199852.1 fimbrial protein -
NG894_RS13380 (NG894_13370) 2691884..2693176 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NG894_RS13385 (NG894_13375) 2693193..2694515 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
NG894_RS13390 (NG894_13380) 2694515..2694781 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NG894_RS13395 (NG894_13385) 2695047..2695373 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NG894_RS13400 (NG894_13390) 2695370..2695870 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NG894_RS13405 (NG894_13395) 2695848..2697227 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
NG894_RS13410 (NG894_13400) 2697573..2698727 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NG894_RS13415 (NG894_13405) 2698708..2699631 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T249064 WP_004199851.1 NZ_CP099522:c2694515-2693193 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT249064 WP_002904790.1 NZ_CP099522:c2694781-2694515 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References