Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 842769..843423 Replicon chromosome
Accession NZ_CP099522
Organism Klebsiella pneumoniae strain SZS128

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag NG894_RS04270 Protein ID WP_004144731.1
Coordinates 843016..843423 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NG894_RS04265 Protein ID WP_002916312.1
Coordinates 842769..843035 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NG894_RS04240 (NG894_04240) 837925..839358 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
NG894_RS04245 (NG894_04245) 839477..840205 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NG894_RS04250 (NG894_04250) 840255..840566 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
NG894_RS04255 (NG894_04255) 840730..841389 + 660 WP_002916317.1 hemolysin III family protein -
NG894_RS04260 (NG894_04260) 841540..842523 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NG894_RS04265 (NG894_04265) 842769..843035 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NG894_RS04270 (NG894_04270) 843016..843423 + 408 WP_004144731.1 protein YgfX Toxin
NG894_RS04275 (NG894_04275) 843430..843951 - 522 WP_002916308.1 flavodoxin FldB -
NG894_RS04280 (NG894_04280) 844052..844948 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NG894_RS04285 (NG894_04285) 844971..845684 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NG894_RS04290 (NG894_04290) 845690..847423 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T249059 WP_004144731.1 NZ_CP099522:843016-843423 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT249059 WP_002916312.1 NZ_CP099522:842769-843035 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References