Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4776163..4776820 Replicon chromosome
Accession NZ_CP099513
Organism Klebsiella sp. ZYC-1

Toxin (Protein)


Gene name cptA Uniprot ID A0A9E1DA00
Locus tag NDO58_RS22385 Protein ID WP_024358614.1
Coordinates 4776163..4776573 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag NDO58_RS22390 Protein ID WP_004124953.1
Coordinates 4776554..4776820 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDO58_RS22365 (NDO58_22335) 4772140..4773873 - 1734 WP_049090244.1 single-stranded-DNA-specific exonuclease RecJ -
NDO58_RS22370 (NDO58_22340) 4773879..4774592 - 714 WP_004134425.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NDO58_RS22375 (NDO58_22345) 4774615..4775511 - 897 WP_004124942.1 site-specific tyrosine recombinase XerD -
NDO58_RS22380 (NDO58_22350) 4775633..4776154 + 522 WP_024358613.1 flavodoxin FldB -
NDO58_RS22385 (NDO58_22355) 4776163..4776573 - 411 WP_024358614.1 protein YgfX Toxin
NDO58_RS22390 (NDO58_22360) 4776554..4776820 - 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
NDO58_RS22395 (NDO58_22365) 4777065..4778048 + 984 WP_024358615.1 tRNA-modifying protein YgfZ -
NDO58_RS22400 (NDO58_22370) 4778175..4778834 - 660 WP_004124978.1 hemolysin III family protein -
NDO58_RS22405 (NDO58_22375) 4778997..4779308 - 312 WP_004133599.1 N(4)-acetylcytidine aminohydrolase -
NDO58_RS22410 (NDO58_22380) 4779359..4780087 + 729 WP_024358621.1 MurR/RpiR family transcriptional regulator -
NDO58_RS22415 (NDO58_22385) 4780209..4781642 + 1434 WP_024358622.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16135.97 Da        Isoelectric Point: 10.9455

>T249055 WP_024358614.1 NZ_CP099513:c4776573-4776163 [Klebsiella sp. ZYC-1]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWEIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT249055 WP_004124953.1 NZ_CP099513:c4776820-4776554 [Klebsiella sp. ZYC-1]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References