249054

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 4738744..4739453 Replicon chromosome
Accession NZ_CP099513
Organism Klebsiella sp. ZYC-1

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag NDO58_RS22160 Protein ID WP_029602169.1
Coordinates 4738744..4739067 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag NDO58_RS22165 Protein ID WP_098067228.1
Coordinates 4739103..4739453 (-) Length 117 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDO58_RS22135 (NDO58_22105) 4734204..4735853 + 1650 WP_102650118.1 OFA family MFS transporter -
NDO58_RS22140 (NDO58_22110) 4735895..4736053 - 159 WP_004134456.1 AAA family ATPase -
NDO58_RS22145 (NDO58_22115) 4736246..4736671 - 426 WP_024358596.1 glutaredoxin-dependent arsenate reductase -
NDO58_RS22150 (NDO58_22120) 4736681..4737973 - 1293 WP_064343183.1 arsenic transporter -
NDO58_RS22155 (NDO58_22125) 4738026..4738376 - 351 WP_004134443.1 transcriptional regulator -
NDO58_RS22160 (NDO58_22130) 4738744..4739067 - 324 WP_029602169.1 TA system toxin CbtA family protein Toxin
NDO58_RS22165 (NDO58_22135) 4739103..4739453 - 351 WP_098067228.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NDO58_RS22170 (NDO58_22140) 4739474..4739695 - 222 WP_098067229.1 DUF987 domain-containing protein -
NDO58_RS22175 (NDO58_22145) 4739710..4740183 - 474 WP_209573830.1 DNA repair protein RadC -
NDO58_RS22180 (NDO58_22150) 4740254..4740463 - 210 Protein_4334 DUF932 domain-containing protein -
NDO58_RS22185 (NDO58_22155) 4740678..4741571 - 894 WP_286454008.1 50S ribosome-binding GTPase -
NDO58_RS22190 (NDO58_22160) 4741669..4742820 + 1152 WP_141522397.1 hypothetical protein -
NDO58_RS22195 (NDO58_22165) 4743221..4743460 + 240 WP_004129359.1 AlpA family phage regulatory protein -
NDO58_RS22200 (NDO58_22170) 4743739..4744317 + 579 WP_098067235.1 inovirus-type Gp2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-106)

Antitoxin

Antitoxin CbeA

(15-115)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12271.15 Da        Isoelectric Point: 6.4617

>T249054 WP_029602169.1 NZ_CP099513:c4739067-4738744 [Klebsiella sp. ZYC-1]
MNTLPAINQRAVQPYPSPVVVWQMLLARLLEQHYGLTLNDTPFSDEAVIKGHIEAGITLVDAVNFLVEKYELVRVDQRGF
SWQEQAPYLTIVDIMRARRYLGITNRS

Download         Length: 324 bp

Antitoxin


Download         Length: 117 a.a.        Molecular weight: 12916.67 Da        Isoelectric Point: 5.5068

>AT249054 WP_098067228.1 NZ_CP099513:c4739453-4739103 [Klebsiella sp. ZYC-1]
MSNKTLTANDDTAEPWWGLSRNVIPCFGARMVQEGNRLHYLADRASITGQFNEADLLHLDQAFPVLLKQVELMLTSGELN
PRHQHCVTLYAKGLTCEADTLGSCGYVYIAIYPTQS

Download         Length: 351 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References