249046

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 26853..27463 Replicon chromosome
Accession NZ_CP099513
Organism Klebsiella sp. ZYC-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NDO58_RS00125 Protein ID WP_098363641.1
Coordinates 27089..27463 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NDO58_RS00120 Protein ID WP_077253475.1
Coordinates 26853..27092 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDO58_RS00095 (NDO58_00095) 22839..23438 + 600 WP_024360709.1 glucose-1-phosphatase -
NDO58_RS00100 (NDO58_00100) 23432..24292 + 861 WP_286454087.1 virulence factor BrkB family protein -
NDO58_RS00105 (NDO58_00105) 24289..24726 + 438 WP_004132870.1 D-aminoacyl-tRNA deacylase -
NDO58_RS00110 (NDO58_00110) 24771..25712 + 942 WP_004127112.1 fatty acid biosynthesis protein FabY -
NDO58_RS00115 (NDO58_00115) 25730..26647 - 918 WP_024360706.1 alpha/beta hydrolase -
NDO58_RS00120 (NDO58_00120) 26853..27092 + 240 WP_077253475.1 CopG family transcriptional regulator Antitoxin
NDO58_RS00125 (NDO58_00125) 27089..27463 + 375 WP_098363641.1 type II toxin-antitoxin system VapC family toxin Toxin
NDO58_RS00130 (NDO58_00130) 27501..28430 - 930 WP_004132861.1 formate dehydrogenase accessory protein FdhE -
NDO58_RS00135 (NDO58_00135) 28774..29409 - 636 WP_004132860.1 formate dehydrogenase cytochrome b556 subunit -
NDO58_RS00140 (NDO58_00140) 29406..30308 - 903 WP_004122548.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14081.36 Da        Isoelectric Point: 8.4571

>T249046 WP_098363641.1 NZ_CP099513:27089-27463 [Klebsiella sp. ZYC-1]
MIKGPALFDTNILIDLFSGRVEAKQVLEAYPPQNAISLITWTEVMVGAKKYHQEHRTRIALSAFNIIDISQDIAERSVNL
RKEYGMKLPDAIILATAQIHRYELVTRNTKDFFGIPGVITPYHL

Download         Length: 375 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9293.49 Da        Isoelectric Point: 4.3142

>AT249046 WP_077253475.1 NZ_CP099513:26853-27092 [Klebsiella sp. ZYC-1]
MMTGTNMGRILLDLSDDVIKRLEDLKQQRNLPRAELLREAVEQYLERQADTTISNALGIWQGCEEDGVEFERKLREEWQ

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References