Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3717820..3718436 Replicon chromosome
Accession NZ_CP099511
Organism Lelliottia amnigena strain P13

Toxin (Protein)


Gene name vapC Uniprot ID A0A3S5XV95
Locus tag NFJ01_RS17805 Protein ID WP_059180558.1
Coordinates 3718062..3718436 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NFJ01_RS17800 Protein ID WP_252688607.1
Coordinates 3717820..3718062 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ01_RS17770 (NFJ01_17770) 3712865..3713761 + 897 WP_059180553.1 sugar kinase -
NFJ01_RS17775 (NFJ01_17775) 3713796..3714596 + 801 WP_174343766.1 DeoR/GlpR family DNA-binding transcription regulator -
NFJ01_RS17780 (NFJ01_17780) 3714729..3715328 + 600 WP_015961052.1 glucose-1-phosphatase -
NFJ01_RS17785 (NFJ01_17785) 3715322..3716194 + 873 WP_131487116.1 virulence factor BrkB family protein -
NFJ01_RS17790 (NFJ01_17790) 3716191..3716628 + 438 WP_059180556.1 D-aminoacyl-tRNA deacylase -
NFJ01_RS17795 (NFJ01_17795) 3716673..3717614 + 942 WP_041689564.1 fatty acid biosynthesis protein FabY -
NFJ01_RS17800 (NFJ01_17800) 3717820..3718062 + 243 WP_252688607.1 CopG family transcriptional regulator Antitoxin
NFJ01_RS17805 (NFJ01_17805) 3718062..3718436 + 375 WP_059180558.1 type II toxin-antitoxin system VapC family toxin Toxin
NFJ01_RS17810 (NFJ01_17810) 3718475..3719404 - 930 WP_059180559.1 formate dehydrogenase accessory protein FdhE -
NFJ01_RS17815 (NFJ01_17815) 3719401..3720036 - 636 WP_059180560.1 formate dehydrogenase cytochrome b556 subunit -
NFJ01_RS17820 (NFJ01_17820) 3720033..3720956 - 924 WP_015961045.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14003.14 Da        Isoelectric Point: 7.4014

>T249044 WP_059180558.1 NZ_CP099511:3718062-3718436 [Lelliottia amnigena]
MAKGSALFDTNILIDLFSGRAEAKHALESWPPQNAISIITWMEVMVGAKKYHQEHRTRIALSAFNVLGVSQEVAERSVDL
RQEYRMKLPDAIILATAQIHRLELVTRNTKDFGNIPDVVTPYNL

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9482.71 Da        Isoelectric Point: 4.7313

>AT249044 WP_252688607.1 NZ_CP099511:3717820-3718062 [Lelliottia amnigena]
MMAGRYMGRILLDLSDEVIKRLDDLKVHRNVPRAELLREAVEQYLERHDQAESTISDALGLWHGCEEEGVDYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5XV95

Antitoxin

Source ID Structure

References