Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2624758..2625378 Replicon chromosome
Accession NZ_CP099511
Organism Lelliottia amnigena strain P13

Toxin (Protein)


Gene name Hha Uniprot ID A0A2S5C408
Locus tag NFJ01_RS12685 Protein ID WP_012016344.1
Coordinates 2625160..2625378 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3S5XLQ2
Locus tag NFJ01_RS12680 Protein ID WP_059177928.1
Coordinates 2624758..2625132 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ01_RS12670 (NFJ01_12670) 2619884..2621077 + 1194 WP_252686077.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFJ01_RS12675 (NFJ01_12675) 2621100..2624249 + 3150 WP_252686079.1 multidrug efflux RND transporter permease subunit AcrB -
NFJ01_RS12680 (NFJ01_12680) 2624758..2625132 + 375 WP_059177928.1 Hha toxicity modulator TomB Antitoxin
NFJ01_RS12685 (NFJ01_12685) 2625160..2625378 + 219 WP_012016344.1 HHA domain-containing protein Toxin
NFJ01_RS12690 (NFJ01_12690) 2625593..2626144 + 552 WP_174342404.1 maltose O-acetyltransferase -
NFJ01_RS12695 (NFJ01_12695) 2626262..2626750 + 489 WP_252686081.1 YlaC family protein -
NFJ01_RS12700 (NFJ01_12700) 2626701..2628161 - 1461 WP_252686083.1 PLP-dependent aminotransferase family protein -
NFJ01_RS12705 (NFJ01_12705) 2628261..2628971 + 711 WP_252686085.1 GNAT family protein -
NFJ01_RS12710 (NFJ01_12710) 2628968..2629108 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
NFJ01_RS12715 (NFJ01_12715) 2629111..2629371 - 261 WP_012016339.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8631.05 Da        Isoelectric Point: 8.9039

>T249040 WP_012016344.1 NZ_CP099511:2625160-2625378 [Lelliottia amnigena]
MSDKPLTKTDYLMRLRRCQSLDTLERVIEKNKYELPDHELAVFYSAADHRLAELTMNKLYDKIPVSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14550.26 Da        Isoelectric Point: 5.1481

>AT249040 WP_059177928.1 NZ_CP099511:2624758-2625132 [Lelliottia amnigena]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFNNVSRANPVSHSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S5C408

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5XLQ2

References