Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1415032..1416591 Replicon chromosome
Accession NZ_CP099511
Organism Lelliottia amnigena strain P13

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NFJ01_RS06790 Protein ID WP_252687841.1
Coordinates 1415284..1416591 (+) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A3S5XQW5
Locus tag NFJ01_RS06785 Protein ID WP_012017425.1
Coordinates 1415032..1415283 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ01_RS06765 (NFJ01_06765) 1410614..1411576 - 963 WP_252687835.1 mannuronate-specific alginate lyase -
NFJ01_RS06770 (NFJ01_06770) 1411728..1413245 + 1518 WP_252687837.1 alpha/beta hydrolase -
NFJ01_RS06775 (NFJ01_06775) 1413178..1414386 - 1209 WP_252687839.1 MFS transporter -
NFJ01_RS06780 (NFJ01_06780) 1414480..1414944 + 465 WP_174341810.1 helix-turn-helix domain-containing protein -
NFJ01_RS06785 (NFJ01_06785) 1415032..1415283 + 252 WP_012017425.1 helix-turn-helix domain-containing protein Antitoxin
NFJ01_RS06790 (NFJ01_06790) 1415284..1416591 + 1308 WP_252687841.1 type II toxin-antitoxin system HipA family toxin Toxin
NFJ01_RS06795 (NFJ01_06795) 1416732..1417952 + 1221 WP_252687842.1 diguanylate phosphodiesterase -
NFJ01_RS06800 (NFJ01_06800) 1417995..1418756 + 762 WP_202666731.1 thiol:disulfide interchange protein DsbG -
NFJ01_RS06805 (NFJ01_06805) 1418769..1420076 - 1308 WP_252687843.1 glycoside hydrolase family 10 protein -
NFJ01_RS06810 (NFJ01_06810) 1420084..1420371 - 288 WP_059178932.1 VF530 family protein -
NFJ01_RS06815 (NFJ01_06815) 1420735..1421178 - 444 WP_252687844.1 cyclophilin-like fold protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 49199.27 Da        Isoelectric Point: 8.4277

>T249039 WP_252687841.1 NZ_CP099511:1415284-1416591 [Lelliottia amnigena]
MKTSKLTVAMNGTVVGTLYRNGKGAMSWQYAQTWLDTPGARVISQSLPLTPRRQEGEVVYNFFSNLLPDSQAIISRMQTR
FKIPTDHPFDLLASVGRDCVGAIQLYPENSEIPPVTHMQATPLSDNEIAALLEGYRNAPLGMNDDQDFRISIAGAQEKTA
LLWHQNRWQRPNGSTPTSHIFKLPIGKIEQNNIDLSESCENEWLCLRLAREFGFSVAEATLATYADKKVLIVERFDRKWS
RDGKWLMRLPQEDMCQALGYSPALKYESHGGPGIAEIMTLLLGSRRSNQDRETFFRTQIFYWLTGAIDGHAKNYSVFIEP
DSAYVMTPLYDILSAYPVFGPKGISAQKAKMAMALQGKNRQYHWAQIQPRHFPATAERVGFSAIRAKKMMIEMGNATDEV
IERVRQSLPIDFPTHISEAIFNGMTKQAERLIRLE

Download         Length: 1308 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9323.55 Da        Isoelectric Point: 5.0790

>AT249039 WP_012017425.1 NZ_CP099511:1415032-1415283 [Lelliottia amnigena]
MKITTSTMLANAMRDQRKALELTQAEAAERVGMKQTTVSGFEQNPDTSKLETLFRLLSALDLELHVVPRGQASEKDSGWT
QEW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5XQW5

References