Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 42227..42887 Replicon chromosome
Accession NZ_CP099511
Organism Lelliottia amnigena strain P13

Toxin (Protein)


Gene name cptA Uniprot ID A0A3S5XTW2
Locus tag NFJ01_RS00215 Protein ID WP_059177602.1
Coordinates 42474..42887 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A3S5XU93
Locus tag NFJ01_RS00210 Protein ID WP_015960306.1
Coordinates 42227..42493 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ01_RS00185 (NFJ01_00185) 37469..38902 - 1434 WP_059177598.1 6-phospho-beta-glucosidase BglA -
NFJ01_RS00190 (NFJ01_00190) 39018..39749 - 732 WP_059177599.1 MurR/RpiR family transcriptional regulator -
NFJ01_RS00195 (NFJ01_00195) 39802..40113 + 312 WP_252687074.1 N(4)-acetylcytidine aminohydrolase -
NFJ01_RS00200 (NFJ01_00200) 40277..40936 + 660 WP_059177600.1 hemolysin III family protein -
NFJ01_RS00205 (NFJ01_00205) 40979..41959 - 981 WP_252687075.1 tRNA-modifying protein YgfZ -
NFJ01_RS00210 (NFJ01_00210) 42227..42493 + 267 WP_015960306.1 FAD assembly factor SdhE Antitoxin
NFJ01_RS00215 (NFJ01_00215) 42474..42887 + 414 WP_059177602.1 protein YgfX Toxin
NFJ01_RS00220 (NFJ01_00220) 42892..43413 - 522 WP_015960304.1 flavodoxin FldB -
NFJ01_RS00225 (NFJ01_00225) 43514..44410 + 897 WP_252687076.1 site-specific tyrosine recombinase XerD -
NFJ01_RS00230 (NFJ01_00230) 44439..45152 + 714 WP_059177605.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFJ01_RS00235 (NFJ01_00235) 45158..46891 + 1734 WP_252687079.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16260.13 Da        Isoelectric Point: 11.1910

>T249034 WP_059177602.1 NZ_CP099511:42474-42887 [Lelliottia amnigena]
VVLWQSDLRVSWRSQWMSLLLHGMVAAFVLLMPWPLSYTPLWMLLLSLVVFDSVRSQRRINSCQGEIKLLMDSRLRWQGK
EWEIVGTPWMLSFGMMFRLRNVQGGRNQHLWLSADSMDADEWRDLRRMVLQQPTPGR

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10528.00 Da        Isoelectric Point: 5.1340

>AT249034 WP_015960306.1 NZ_CP099511:42227-42493 [Lelliottia amnigena]
MDISNKARIHWACRRGMRELDISVMPFFEYEYDSLSDDDKRLFIRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5XTW2

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5XU93

References