Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2640002..2640531 Replicon chromosome
Accession NZ_CP099508
Organism Staphylococcus aureus strain S82

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LPT18_RS12905 Protein ID WP_000621175.1
Coordinates 2640169..2640531 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag LPT18_RS12900 Protein ID WP_000948331.1
Coordinates 2640002..2640172 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPT18_RS12870 (2635038) 2635038..2635598 + 561 WP_001092419.1 K(+)-transporting ATPase subunit C -
LPT18_RS12875 (2635807) 2635807..2636286 + 480 WP_001287081.1 hypothetical protein -
LPT18_RS12880 (2636279) 2636279..2637856 + 1578 WP_229355880.1 PH domain-containing protein -
LPT18_RS12885 (2637849) 2637849..2638340 + 492 WP_001286980.1 PH domain-containing protein -
LPT18_RS12890 (2638344) 2638344..2638703 + 360 WP_096002285.1 holo-ACP synthase -
LPT18_RS12895 (2638769) 2638769..2639917 + 1149 WP_001281139.1 alanine racemase -
LPT18_RS12900 (2640002) 2640002..2640172 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LPT18_RS12905 (2640169) 2640169..2640531 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LPT18_RS12910 (2640881) 2640881..2641882 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
LPT18_RS12915 (2642001) 2642001..2642327 + 327 WP_001052491.1 anti-sigma factor antagonist -
LPT18_RS12920 (2642329) 2642329..2642808 + 480 WP_001190825.1 anti-sigma B factor RsbW -
LPT18_RS12925 (2642783) 2642783..2643553 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T249033 WP_000621175.1 NZ_CP099508:2640169-2640531 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT249033 WP_000948331.1 NZ_CP099508:2640002-2640172 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References