Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2620280..2620794 Replicon chromosome
Accession NZ_CP099508
Organism Staphylococcus aureus strain S82

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag LPT18_RS12815 Protein ID WP_000581792.1
Coordinates 2620585..2620794 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag LPT18_RS12810 Protein ID WP_000138932.1
Coordinates 2620280..2620573 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPT18_RS12790 (2616043) 2616043..2617358 + 1316 Protein_2482 ISL3 family transposase -
LPT18_RS12795 (2617336) 2617336..2617398 - 63 Protein_2483 hypothetical protein -
LPT18_RS12800 (2617955) 2617955..2618602 - 648 WP_001187614.1 HD domain-containing protein -
LPT18_RS12805 (2618630) 2618630..2620114 - 1485 WP_000571550.1 cardiolipin synthase -
LPT18_RS12810 (2620280) 2620280..2620573 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
LPT18_RS12815 (2620585) 2620585..2620794 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
LPT18_RS12820 (2620922) 2620922..2621059 + 138 WP_000828354.1 Lmo0850 family protein -
LPT18_RS12825 (2621323) 2621323..2622525 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
LPT18_RS12830 (2622843) 2622843..2623913 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
LPT18_RS12835 (2623928) 2623928..2625283 + 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T249032 WP_000581792.1 NZ_CP099508:2620585-2620794 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT249032 WP_000138932.1 NZ_CP099508:2620280-2620573 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References