Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1753517..1754031 Replicon chromosome
Accession NZ_CP099506
Organism Staphylococcus aureus strain 0316-H-5A

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag LPT22_RS08755 Protein ID WP_000581792.1
Coordinates 1753517..1753726 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag LPT22_RS08760 Protein ID WP_000138932.1
Coordinates 1753738..1754031 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPT22_RS08735 (1749028) 1749028..1750383 - 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
LPT22_RS08740 (1750398) 1750398..1751468 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
LPT22_RS08745 (1751786) 1751786..1752988 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
LPT22_RS08750 (1753252) 1753252..1753389 - 138 WP_000828354.1 Lmo0850 family protein -
LPT22_RS08755 (1753517) 1753517..1753726 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
LPT22_RS08760 (1753738) 1753738..1754031 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
LPT22_RS08765 (1754197) 1754197..1755681 + 1485 WP_000571550.1 cardiolipin synthase -
LPT22_RS08770 (1755709) 1755709..1756356 + 648 WP_001187614.1 HD domain-containing protein -
LPT22_RS08775 (1756773) 1756773..1756835 + 63 Protein_1688 hypothetical protein -
LPT22_RS08780 (1756813) 1756813..1758128 - 1316 Protein_1689 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T249017 WP_000581792.1 NZ_CP099506:c1753726-1753517 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT249017 WP_000138932.1 NZ_CP099506:c1754031-1753738 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References