249016

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1733780..1734309 Replicon chromosome
Accession NZ_CP099506
Organism Staphylococcus aureus strain 0316-H-5A

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LPT22_RS08665 Protein ID WP_000621175.1
Coordinates 1733780..1734142 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag LPT22_RS08670 Protein ID WP_000948331.1
Coordinates 1734139..1734309 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPT22_RS08645 (1730758) 1730758..1731528 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
LPT22_RS08650 (1731503) 1731503..1731982 - 480 WP_001190825.1 anti-sigma B factor RsbW -
LPT22_RS08655 (1731984) 1731984..1732310 - 327 WP_001052491.1 anti-sigma factor antagonist -
LPT22_RS08660 (1732429) 1732429..1733430 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
LPT22_RS08665 (1733780) 1733780..1734142 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LPT22_RS08670 (1734139) 1734139..1734309 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LPT22_RS08675 (1734394) 1734394..1735542 - 1149 WP_001281139.1 alanine racemase -
LPT22_RS08680 (1735608) 1735608..1735967 - 360 WP_000581197.1 holo-ACP synthase -
LPT22_RS08685 (1735971) 1735971..1736462 - 492 WP_001286980.1 PH domain-containing protein -
LPT22_RS08690 (1736455) 1736455..1738032 - 1578 WP_001294650.1 PH domain-containing protein -
LPT22_RS08695 (1738025) 1738025..1738504 - 480 WP_001287081.1 hypothetical protein -
LPT22_RS08700 (1738713) 1738713..1739273 - 561 WP_001092419.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T249016 WP_000621175.1 NZ_CP099506:c1734142-1733780 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT249016 WP_000948331.1 NZ_CP099506:c1734309-1734139 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References