Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1532764..1533540 Replicon chromosome
Accession NZ_CP099506
Organism Staphylococcus aureus strain 0316-H-5A

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag LPT22_RS07420 Protein ID WP_000031108.1
Coordinates 1532764..1532916 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag LPT22_RS07425 Protein ID WP_001251224.1
Coordinates 1532941..1533540 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPT22_RS07405 (1528969) 1528969..1529790 + 822 WP_000669380.1 RluA family pseudouridine synthase -
LPT22_RS07410 (1530245) 1530245..1531630 - 1386 WP_000116238.1 class II fumarate hydratase -
LPT22_RS07415 (1531826) 1531826..1532221 - 396 WP_000901018.1 hypothetical protein -
LPT22_RS07420 (1532764) 1532764..1532916 - 153 WP_000031108.1 SAS053 family protein Toxin
LPT22_RS07425 (1532941) 1532941..1533540 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
LPT22_RS07430 (1533699) 1533699..1534169 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
LPT22_RS07435 (1534174) 1534174..1535301 - 1128 WP_229360502.1 tRNA epoxyqueuosine(34) reductase QueG -
LPT22_RS07440 (1535452) 1535452..1536174 - 723 WP_031774878.1 amino acid ABC transporter ATP-binding protein -
LPT22_RS07445 (1536167) 1536167..1537624 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T249011 WP_000031108.1 NZ_CP099506:c1532916-1532764 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT249011 WP_001251224.1 NZ_CP099506:c1533540-1532941 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References