Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2440700..2441476 Replicon chromosome
Accession NZ_CP099504
Organism Staphylococcus aureus strain S36

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag LPT20_RS11895 Protein ID WP_000031108.1
Coordinates 2441324..2441476 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A6B1RP77
Locus tag LPT20_RS11890 Protein ID WP_001251218.1
Coordinates 2440700..2441299 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPT20_RS11870 (LPT20_11870) 2436616..2438073 + 1458 WP_000649908.1 ABC transporter permease subunit -
LPT20_RS11875 (LPT20_11875) 2438066..2438788 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
LPT20_RS11880 (LPT20_11880) 2438939..2440066 + 1128 WP_000379977.1 tRNA epoxyqueuosine(34) reductase QueG -
LPT20_RS11885 (LPT20_11885) 2440071..2440541 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
LPT20_RS11890 (LPT20_11890) 2440700..2441299 + 600 WP_001251218.1 glucosamine-6-phosphate isomerase Antitoxin
LPT20_RS11895 (LPT20_11895) 2441324..2441476 + 153 WP_000031108.1 SAS053 family protein Toxin
LPT20_RS11900 (LPT20_11900) 2442139..2442534 + 396 WP_000901022.1 hypothetical protein -
LPT20_RS11905 (LPT20_11905) 2442730..2444115 + 1386 WP_000116233.1 class II fumarate hydratase -
LPT20_RS11910 (LPT20_11910) 2444580..2445401 - 822 WP_000669384.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T249007 WP_000031108.1 NZ_CP099504:2441324-2441476 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT249007 WP_001251218.1 NZ_CP099504:2440700-2441299 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFIVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A6B1RP77

References