Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2288696..2289225 Replicon chromosome
Accession NZ_CP099504
Organism Staphylococcus aureus strain S36

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LPT20_RS11015 Protein ID WP_000621175.1
Coordinates 2288863..2289225 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag LPT20_RS11010 Protein ID WP_000948331.1
Coordinates 2288696..2288866 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPT20_RS10980 (LPT20_10980) 2283732..2284292 + 561 WP_001092405.1 K(+)-transporting ATPase subunit C -
LPT20_RS10985 (LPT20_10985) 2284501..2284980 + 480 WP_001287083.1 hypothetical protein -
LPT20_RS10990 (LPT20_10990) 2284973..2286556 + 1584 WP_001294642.1 PH domain-containing protein -
LPT20_RS10995 (LPT20_10995) 2286543..2287034 + 492 WP_001205915.1 PH domain-containing protein -
LPT20_RS11000 (LPT20_11000) 2287038..2287397 + 360 WP_000581194.1 holo-ACP synthase -
LPT20_RS11005 (LPT20_11005) 2287463..2288611 + 1149 WP_001280702.1 alanine racemase -
LPT20_RS11010 (LPT20_11010) 2288696..2288866 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LPT20_RS11015 (LPT20_11015) 2288863..2289225 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LPT20_RS11020 (LPT20_11020) 2289574..2290575 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
LPT20_RS11025 (LPT20_11025) 2290694..2291020 + 327 WP_001052491.1 anti-sigma factor antagonist -
LPT20_RS11030 (LPT20_11030) 2291022..2291501 + 480 WP_001190825.1 anti-sigma B factor RsbW -
LPT20_RS11035 (LPT20_11035) 2291476..2292246 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T249006 WP_000621175.1 NZ_CP099504:2288863-2289225 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT249006 WP_000948331.1 NZ_CP099504:2288696-2288866 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References