Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2268971..2269485 Replicon chromosome
Accession NZ_CP099504
Organism Staphylococcus aureus strain S36

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag LPT20_RS10925 Protein ID WP_000581792.1
Coordinates 2269276..2269485 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag LPT20_RS10920 Protein ID WP_000138934.1
Coordinates 2268971..2269264 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPT20_RS10900 (LPT20_10900) 2264232..2264873 + 642 WP_000483147.1 thiamine phosphate synthase -
LPT20_RS10905 (LPT20_10905) 2264959..2265831 + 873 WP_000725802.1 membrane protein insertase YidC -
LPT20_RS10910 (LPT20_10910) 2266646..2267293 - 648 WP_001187610.1 HD domain-containing protein -
LPT20_RS10915 (LPT20_10915) 2267321..2268805 - 1485 WP_000571549.1 cardiolipin synthase -
LPT20_RS10920 (LPT20_10920) 2268971..2269264 + 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
LPT20_RS10925 (LPT20_10925) 2269276..2269485 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
LPT20_RS10930 (LPT20_10930) 2269613..2269750 + 138 WP_000828354.1 Lmo0850 family protein -
LPT20_RS10935 (LPT20_10935) 2270014..2271216 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
LPT20_RS10940 (LPT20_10940) 2271534..2272604 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
LPT20_RS10945 (LPT20_10945) 2272619..2273977 + 1359 WP_000611468.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T249005 WP_000581792.1 NZ_CP099504:2269276-2269485 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT249005 WP_000138934.1 NZ_CP099504:2268971-2269264 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References