248999

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 1723649..1724757 Replicon chromosome
Accession NZ_CP099504
Organism Staphylococcus aureus strain S36

Toxin (Protein)


Gene name MNTss Uniprot ID R3JIN1
Locus tag LPT20_RS08155 Protein ID WP_000233000.1
Coordinates 1723888..1724757 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag LPT20_RS08150 Protein ID WP_000205227.1
Coordinates 1723649..1723873 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPT20_RS08120 (LPT20_08120) 1719238..1719408 + 171 WP_000713595.1 hypothetical protein -
LPT20_RS08125 (LPT20_08125) 1719422..1720040 + 619 Protein_1599 recombinase family protein -
LPT20_RS08130 (LPT20_08130) 1720040..1720717 + 678 Protein_1600 DNA topoisomerase -
LPT20_RS08135 (LPT20_08135) 1721199..1721525 + 327 WP_000392725.1 hypothetical protein -
LPT20_RS08140 (LPT20_08140) 1721526..1721942 + 417 WP_000323438.1 recombinase -
LPT20_RS08145 (LPT20_08145) 1721962..1723506 + 1545 WP_002390960.1 recombinase family protein -
LPT20_RS08150 (LPT20_08150) 1723649..1723873 + 225 WP_000205227.1 helix-turn-helix transcriptional regulator Antitoxin
LPT20_RS08155 (LPT20_08155) 1723888..1724757 + 870 WP_000233000.1 nucleotidyltransferase domain-containing protein Toxin
LPT20_RS08160 (LPT20_08160) 1724738..1725472 + 735 WP_000662263.1 class I SAM-dependent methyltransferase -
LPT20_RS08165 (LPT20_08165) 1725505..1726413 + 909 WP_001255866.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
LPT20_RS08170 (LPT20_08170) 1726410..1726890 + 481 Protein_1608 GNAT family N-acetyltransferase -
LPT20_RS08175 (LPT20_08175) 1726983..1727777 + 795 WP_001096887.1 aminoglycoside O-phosphotransferase APH(3')-IIIa -
LPT20_RS14400 1728187..1728270 + 84 Protein_1610 MLS leader peptide -
LPT20_RS08180 (LPT20_08180) 1728319..1728402 + 84 WP_001814874.1 23S rRNA methyltransferase attenuation leader peptide -
LPT20_RS08185 (LPT20_08185) 1728527..1729264 + 738 WP_001038790.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage cat(pC233) / ant(6)-Ia / aph(3')-III / erm(B) - 1710985..1734180 23195
- flank IS/Tn ant(6)-Ia / aph(3')-III / erm(B) - 1725505..1734180 8675


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32926.57 Da        Isoelectric Point: 4.8781

>T248999 WP_000233000.1 NZ_CP099504:1723888-1724757 [Staphylococcus aureus]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8365.68 Da        Isoelectric Point: 4.5510

>AT248999 WP_000205227.1 NZ_CP099504:1723649-1723873 [Staphylococcus aureus]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3JIN1

Antitoxin

Source ID Structure

References