Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2614242..2614771 Replicon chromosome
Accession NZ_CP099502
Organism Staphylococcus aureus strain JL42

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LPT17_RS12800 Protein ID WP_000621175.1
Coordinates 2614409..2614771 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag LPT17_RS12795 Protein ID WP_000948331.1
Coordinates 2614242..2614412 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPT17_RS12765 (2609278) 2609278..2609838 + 561 WP_001092419.1 K(+)-transporting ATPase subunit C -
LPT17_RS12770 (2610047) 2610047..2610526 + 480 WP_001287081.1 hypothetical protein -
LPT17_RS12775 (2610519) 2610519..2612096 + 1578 WP_001294650.1 PH domain-containing protein -
LPT17_RS12780 (2612089) 2612089..2612580 + 492 WP_001286980.1 PH domain-containing protein -
LPT17_RS12785 (2612584) 2612584..2612943 + 360 WP_096002285.1 holo-ACP synthase -
LPT17_RS12790 (2613009) 2613009..2614157 + 1149 WP_001281139.1 alanine racemase -
LPT17_RS12795 (2614242) 2614242..2614412 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LPT17_RS12800 (2614409) 2614409..2614771 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LPT17_RS12805 (2615120) 2615120..2616121 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
LPT17_RS12810 (2616240) 2616240..2616566 + 327 WP_001052491.1 anti-sigma factor antagonist -
LPT17_RS12815 (2616568) 2616568..2617047 + 480 WP_001190825.1 anti-sigma B factor RsbW -
LPT17_RS12820 (2617022) 2617022..2617792 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T248996 WP_000621175.1 NZ_CP099502:2614409-2614771 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT248996 WP_000948331.1 NZ_CP099502:2614242-2614412 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References