Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2594520..2595034 Replicon chromosome
Accession NZ_CP099502
Organism Staphylococcus aureus strain JL42

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag LPT17_RS12710 Protein ID WP_000581792.1
Coordinates 2594825..2595034 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag LPT17_RS12705 Protein ID WP_000138932.1
Coordinates 2594520..2594813 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPT17_RS12685 (2590283) 2590283..2591598 + 1316 Protein_2462 ISL3 family transposase -
LPT17_RS12690 (2591576) 2591576..2591638 - 63 Protein_2463 hypothetical protein -
LPT17_RS12695 (2592195) 2592195..2592842 - 648 WP_001187614.1 HD domain-containing protein -
LPT17_RS12700 (2592870) 2592870..2594354 - 1485 WP_000571550.1 cardiolipin synthase -
LPT17_RS12705 (2594520) 2594520..2594813 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
LPT17_RS12710 (2594825) 2594825..2595034 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
LPT17_RS12715 (2595162) 2595162..2595299 + 138 WP_000828354.1 Lmo0850 family protein -
LPT17_RS12720 (2595563) 2595563..2596765 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
LPT17_RS12725 (2597083) 2597083..2598153 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
LPT17_RS12730 (2598168) 2598168..2599523 + 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T248995 WP_000581792.1 NZ_CP099502:2594825-2595034 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT248995 WP_000138932.1 NZ_CP099502:2594520-2594813 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References