Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1709889..1710403 Replicon chromosome
Accession NZ_CP099499
Organism Staphylococcus aureus strain 0610-H-2A

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag LPT19_RS08410 Protein ID WP_000581792.1
Coordinates 1709889..1710098 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag LPT19_RS08415 Protein ID WP_000138932.1
Coordinates 1710110..1710403 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPT19_RS08390 (LPT19_08390) 1705400..1706755 - 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
LPT19_RS08395 (LPT19_08395) 1706770..1707840 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
LPT19_RS08400 (LPT19_08400) 1708158..1709360 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
LPT19_RS08405 (LPT19_08405) 1709624..1709761 - 138 WP_000828354.1 Lmo0850 family protein -
LPT19_RS08410 (LPT19_08410) 1709889..1710098 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
LPT19_RS08415 (LPT19_08415) 1710110..1710403 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
LPT19_RS08420 (LPT19_08420) 1710569..1712053 + 1485 WP_000571550.1 cardiolipin synthase -
LPT19_RS08425 (LPT19_08425) 1712081..1712728 + 648 WP_001187614.1 HD domain-containing protein -
LPT19_RS08430 (LPT19_08430) 1713285..1713347 + 63 Protein_1617 hypothetical protein -
LPT19_RS08435 (LPT19_08435) 1713325..1714640 - 1316 Protein_1618 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T248980 WP_000581792.1 NZ_CP099499:c1710098-1709889 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T248980 NZ_CP099499:c1710098-1709889 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT248980 WP_000138932.1 NZ_CP099499:c1710403-1710110 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT248980 NZ_CP099499:c1710403-1710110 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References