Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1690152..1690681 Replicon chromosome
Accession NZ_CP099499
Organism Staphylococcus aureus strain 0610-H-2A

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LPT19_RS08320 Protein ID WP_000621175.1
Coordinates 1690152..1690514 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag LPT19_RS08325 Protein ID WP_000948331.1
Coordinates 1690511..1690681 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPT19_RS08300 (LPT19_08300) 1687130..1687900 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
LPT19_RS08305 (LPT19_08305) 1687875..1688354 - 480 WP_001190825.1 anti-sigma B factor RsbW -
LPT19_RS08310 (LPT19_08310) 1688356..1688682 - 327 WP_001052491.1 anti-sigma factor antagonist -
LPT19_RS08315 (LPT19_08315) 1688801..1689802 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
LPT19_RS08320 (LPT19_08320) 1690152..1690514 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LPT19_RS08325 (LPT19_08325) 1690511..1690681 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LPT19_RS08330 (LPT19_08330) 1690766..1691914 - 1149 WP_001281139.1 alanine racemase -
LPT19_RS08335 (LPT19_08335) 1691980..1692339 - 360 WP_000581197.1 holo-ACP synthase -
LPT19_RS08340 (LPT19_08340) 1692343..1692834 - 492 WP_001286980.1 PH domain-containing protein -
LPT19_RS08345 (LPT19_08345) 1692827..1694404 - 1578 WP_001294650.1 PH domain-containing protein -
LPT19_RS08350 (LPT19_08350) 1694397..1694876 - 480 WP_001287081.1 hypothetical protein -
LPT19_RS08355 (LPT19_08355) 1695085..1695645 - 561 WP_001092419.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T248979 WP_000621175.1 NZ_CP099499:c1690514-1690152 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT248979 WP_000948331.1 NZ_CP099499:c1690681-1690511 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References