Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1528504..1529280 Replicon chromosome
Accession NZ_CP099499
Organism Staphylococcus aureus strain 0610-H-2A

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag LPT19_RS07400 Protein ID WP_000031108.1
Coordinates 1528504..1528656 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag LPT19_RS07405 Protein ID WP_001251224.1
Coordinates 1528681..1529280 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPT19_RS07385 (LPT19_07385) 1524709..1525530 + 822 WP_000669380.1 RluA family pseudouridine synthase -
LPT19_RS07390 (LPT19_07390) 1525985..1527370 - 1386 WP_000116238.1 class II fumarate hydratase -
LPT19_RS07395 (LPT19_07395) 1527566..1527961 - 396 WP_000901018.1 hypothetical protein -
LPT19_RS07400 (LPT19_07400) 1528504..1528656 - 153 WP_000031108.1 SAS053 family protein Toxin
LPT19_RS07405 (LPT19_07405) 1528681..1529280 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
LPT19_RS07410 (LPT19_07410) 1529439..1529909 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
LPT19_RS07415 (LPT19_07415) 1529914..1531041 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
LPT19_RS07420 (LPT19_07420) 1531192..1531914 - 723 WP_031774878.1 amino acid ABC transporter ATP-binding protein -
LPT19_RS07425 (LPT19_07425) 1531907..1533364 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T248978 WP_000031108.1 NZ_CP099499:c1528656-1528504 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT248978 WP_001251224.1 NZ_CP099499:c1529280-1528681 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References