Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1716002..1716516 Replicon chromosome
Accession NZ_CP099497
Organism Staphylococcus aureus strain 0213-M-4A

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag LPT21_RS08415 Protein ID WP_000581792.1
Coordinates 1716002..1716211 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag LPT21_RS08420 Protein ID WP_000138932.1
Coordinates 1716223..1716516 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPT21_RS08395 (LPT21_08395) 1711513..1712868 - 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
LPT21_RS08400 (LPT21_08400) 1712883..1713953 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
LPT21_RS08405 (LPT21_08405) 1714271..1715473 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
LPT21_RS08410 (LPT21_08410) 1715737..1715874 - 138 WP_000828354.1 Lmo0850 family protein -
LPT21_RS08415 (LPT21_08415) 1716002..1716211 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
LPT21_RS08420 (LPT21_08420) 1716223..1716516 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
LPT21_RS08425 (LPT21_08425) 1716682..1718166 + 1485 WP_000571550.1 cardiolipin synthase -
LPT21_RS08430 (LPT21_08430) 1718194..1718841 + 648 WP_001187614.1 HD domain-containing protein -
LPT21_RS08435 (LPT21_08435) 1719398..1719460 + 63 Protein_1618 hypothetical protein -
LPT21_RS08440 (LPT21_08440) 1719438..1720753 - 1316 Protein_1619 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T248971 WP_000581792.1 NZ_CP099497:c1716211-1716002 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT248971 WP_000138932.1 NZ_CP099497:c1716516-1716223 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References