Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1696265..1696794 Replicon chromosome
Accession NZ_CP099497
Organism Staphylococcus aureus strain 0213-M-4A

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LPT21_RS08325 Protein ID WP_000621175.1
Coordinates 1696265..1696627 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag LPT21_RS08330 Protein ID WP_000948331.1
Coordinates 1696624..1696794 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPT21_RS08305 (LPT21_08305) 1693243..1694013 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
LPT21_RS08310 (LPT21_08310) 1693988..1694467 - 480 WP_001190825.1 anti-sigma B factor RsbW -
LPT21_RS08315 (LPT21_08315) 1694469..1694795 - 327 WP_001052491.1 anti-sigma factor antagonist -
LPT21_RS08320 (LPT21_08320) 1694914..1695915 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
LPT21_RS08325 (LPT21_08325) 1696265..1696627 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LPT21_RS08330 (LPT21_08330) 1696624..1696794 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LPT21_RS08335 (LPT21_08335) 1696879..1698027 - 1149 WP_001281139.1 alanine racemase -
LPT21_RS08340 (LPT21_08340) 1698093..1698452 - 360 WP_000581197.1 holo-ACP synthase -
LPT21_RS08345 (LPT21_08345) 1698456..1698947 - 492 WP_001286980.1 PH domain-containing protein -
LPT21_RS08350 (LPT21_08350) 1698940..1700517 - 1578 WP_001294650.1 PH domain-containing protein -
LPT21_RS08355 (LPT21_08355) 1700510..1700989 - 480 WP_001287081.1 hypothetical protein -
LPT21_RS08360 (LPT21_08360) 1701198..1701758 - 561 WP_001092419.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T248970 WP_000621175.1 NZ_CP099497:c1696627-1696265 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT248970 WP_000948331.1 NZ_CP099497:c1696794-1696624 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References