Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1534634..1535410 Replicon chromosome
Accession NZ_CP099497
Organism Staphylococcus aureus strain 0213-M-4A

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag LPT21_RS07405 Protein ID WP_000031108.1
Coordinates 1534634..1534786 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag LPT21_RS07410 Protein ID WP_001251224.1
Coordinates 1534811..1535410 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPT21_RS07390 (LPT21_07390) 1530839..1531660 + 822 WP_000669380.1 RluA family pseudouridine synthase -
LPT21_RS07395 (LPT21_07395) 1532115..1533500 - 1386 WP_000116238.1 class II fumarate hydratase -
LPT21_RS07400 (LPT21_07400) 1533696..1534091 - 396 WP_000901018.1 hypothetical protein -
LPT21_RS07405 (LPT21_07405) 1534634..1534786 - 153 WP_000031108.1 SAS053 family protein Toxin
LPT21_RS07410 (LPT21_07410) 1534811..1535410 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
LPT21_RS07415 (LPT21_07415) 1535569..1536039 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
LPT21_RS07420 (LPT21_07420) 1536044..1537171 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
LPT21_RS07425 (LPT21_07425) 1537322..1538044 - 723 WP_031774878.1 amino acid ABC transporter ATP-binding protein -
LPT21_RS07430 (LPT21_07430) 1538037..1539494 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T248969 WP_000031108.1 NZ_CP099497:c1534786-1534634 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT248969 WP_001251224.1 NZ_CP099497:c1535410-1534811 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References