Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2638197..2638726 Replicon chromosome
Accession NZ_CP099495
Organism Staphylococcus aureus strain JL28

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LPT16_RS12905 Protein ID WP_000621175.1
Coordinates 2638364..2638726 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag LPT16_RS12900 Protein ID WP_000948331.1
Coordinates 2638197..2638367 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPT16_RS12870 (2633233) 2633233..2633793 + 561 WP_001092419.1 K(+)-transporting ATPase subunit C -
LPT16_RS12875 (2634002) 2634002..2634481 + 480 WP_001287081.1 hypothetical protein -
LPT16_RS12880 (2634474) 2634474..2636051 + 1578 WP_001294650.1 PH domain-containing protein -
LPT16_RS12885 (2636044) 2636044..2636535 + 492 WP_001286980.1 PH domain-containing protein -
LPT16_RS12890 (2636539) 2636539..2636898 + 360 WP_096002285.1 holo-ACP synthase -
LPT16_RS12895 (2636964) 2636964..2638112 + 1149 WP_001281139.1 alanine racemase -
LPT16_RS12900 (2638197) 2638197..2638367 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LPT16_RS12905 (2638364) 2638364..2638726 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LPT16_RS12910 (2639076) 2639076..2640077 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
LPT16_RS12915 (2640196) 2640196..2640522 + 327 WP_001052491.1 anti-sigma factor antagonist -
LPT16_RS12920 (2640524) 2640524..2641003 + 480 WP_001190825.1 anti-sigma B factor RsbW -
LPT16_RS12925 (2640978) 2640978..2641748 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T248967 WP_000621175.1 NZ_CP099495:2638364-2638726 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT248967 WP_000948331.1 NZ_CP099495:2638197-2638367 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References