248960

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 119272..120048 Replicon chromosome
Accession NZ_CP099495
Organism Staphylococcus aureus strain JL28

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag LPT16_RS00765 Protein ID WP_000031108.1
Coordinates 119896..120048 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag LPT16_RS00760 Protein ID WP_001251224.1
Coordinates 119272..119871 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPT16_RS00740 (115188) 115188..116645 + 1458 WP_000649908.1 ABC transporter permease subunit -
LPT16_RS00745 (116638) 116638..117360 + 723 WP_031774878.1 amino acid ABC transporter ATP-binding protein -
LPT16_RS00750 (117511) 117511..118638 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
LPT16_RS00755 (118643) 118643..119113 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
LPT16_RS00760 (119272) 119272..119871 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
LPT16_RS00765 (119896) 119896..120048 + 153 WP_000031108.1 SAS053 family protein Toxin
LPT16_RS00770 (120591) 120591..120986 + 396 WP_000901018.1 hypothetical protein -
LPT16_RS00775 (121182) 121182..122567 + 1386 WP_000116238.1 class II fumarate hydratase -
LPT16_RS00780 (123022) 123022..123843 - 822 WP_000669380.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T248960 WP_000031108.1 NZ_CP099495:119896-120048 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT248960 WP_001251224.1 NZ_CP099495:119272-119871 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References