Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1278142..1278767 Replicon chromosome
Accession NC_014500
Organism Dickeya dadantii 3937

Toxin (Protein)


Gene name Hha Uniprot ID E0SD87
Locus tag DDA3937_RS05720 Protein ID WP_009114000.1
Coordinates 1278142..1278345 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID E0SD88
Locus tag DDA3937_RS05725 Protein ID WP_013316870.1
Coordinates 1278399..1278767 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DDA3937_RS05695 (Dda3937_03309) 1273800..1274138 + 339 WP_002208627.1 P-II family nitrogen regulator -
DDA3937_RS05700 (Dda3937_03308) 1274181..1275473 + 1293 WP_013316866.1 ammonium transporter AmtB -
DDA3937_RS05705 (Dda3937_03307) 1275569..1276432 - 864 WP_013316867.1 acyl-CoA thioesterase II -
DDA3937_RS05710 (Dda3937_03306) 1276667..1277224 + 558 WP_013316868.1 YbaY family lipoprotein -
DDA3937_RS05715 (Dda3937_03305) 1277255..1277584 - 330 WP_033111686.1 MGMT family protein -
DDA3937_RS05720 (Dda3937_03304) 1278142..1278345 - 204 WP_009114000.1 hemolysin expression modulator Hha Toxin
DDA3937_RS05725 (Dda3937_03303) 1278399..1278767 - 369 WP_013316870.1 Hha toxicity modulator TomB Antitoxin
DDA3937_RS21985 (Dda3937_03302) 1279275..1279418 - 144 WP_013316871.1 type B 50S ribosomal protein L36 -
DDA3937_RS05730 (Dda3937_03301) 1279434..1279685 - 252 WP_013316872.1 type B 50S ribosomal protein L31 -
DDA3937_RS05735 (Dda3937_03300) 1279865..1283011 - 3147 WP_013316873.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.51 Da        Isoelectric Point: 8.8500

>T24895 WP_009114000.1 NC_014500:c1278345-1278142 [Dickeya dadantii 3937]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Download         Length: 204 bp

>T24895 NC_014500:c1278345-1278142 [Dickeya dadantii 3937]
ATGAAAAAAATCGACTATTTAATGCGTTTGCGTAAATGTACAACCATCGACACGCTTGAACGTGTTATAGAAAAAAACAA
GTACGAGCTTTCCAACGACGAGCTTGAAATGTTCTATTCAGCTGCAGACCACCGCCTGGCAGAGCTGACGATGAATAAAC
TTTACGACAAAGTACCGACTGCTGTGTGGAAATACGTTCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14242.11 Da        Isoelectric Point: 5.1811

>AT24895 WP_013316870.1 NC_014500:c1278767-1278399 [Dickeya dadantii 3937]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSRGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDTELRKWQKSKSQLFRMFSEKSICTVVKT

Download         Length: 369 bp

>AT24895 NC_014500:c1278767-1278399 [Dickeya dadantii 3937]
ATGGATGAGTACACACCTCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGACGAAAGTATCGC
GACATTAGGTGACAGCAGTCGTGGCTGGGTGAATGATCCGACCTCTGCGGTCAACCTTCAACTAAACGAACTTATCGAAC
ATATTGCGGCATTTGTTGTTACCTACAAAATAAAATATCCGCATGAAGCGGCGTTATGTGAACGGGTTGAGAAATATCTG
GACGACACTTATATTCTTTTCAGCAATTACGGTATAAATGACACCGAGTTGCGGAAATGGCAAAAATCCAAGTCACAATT
ATTCAGAATGTTCTCAGAAAAGAGCATCTGTACGGTAGTAAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3RNQ0

Antitoxin

Source ID Structure
AlphaFold DB E0SD88

References