Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 137898..138580 Replicon chromosome
Accession NZ_CP099490
Organism Ornithinimicrobium cryptoxanthini strain JY.X270

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NF557_RS00595 Protein ID WP_252621167.1
Coordinates 137898..138320 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NF557_RS00600 Protein ID WP_252621168.1
Coordinates 138323..138580 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF557_RS00555 (NF557_00555) 132978..133214 - 237 WP_252621159.1 heavy metal-associated domain-containing protein -
NF557_RS00560 (NF557_00560) 133390..134091 + 702 WP_252621160.1 lysoplasmalogenase family protein -
NF557_RS00565 (NF557_00565) 134122..135267 + 1146 WP_252621161.1 aminoglycoside phosphotransferase family protein -
NF557_RS00570 (NF557_00570) 135384..135560 + 177 WP_252621162.1 hypothetical protein -
NF557_RS00575 (NF557_00575) 135591..136385 - 795 WP_252621163.1 enoyl-CoA hydratase -
NF557_RS00580 (NF557_00580) 136479..136826 + 348 WP_252621164.1 PadR family transcriptional regulator -
NF557_RS00585 (NF557_00585) 136823..137464 + 642 WP_252621165.1 hypothetical protein -
NF557_RS00590 (NF557_00590) 137454..137864 - 411 WP_252621166.1 YchJ family metal-binding protein -
NF557_RS00595 (NF557_00595) 137898..138320 - 423 WP_252621167.1 type II toxin-antitoxin system VapC family toxin Toxin
NF557_RS00600 (NF557_00600) 138323..138580 - 258 WP_252621168.1 antitoxin Antitoxin
NF557_RS00605 (NF557_00605) 138627..139208 - 582 WP_252621169.1 DUF4262 domain-containing protein -
NF557_RS00610 (NF557_00610) 139317..140813 + 1497 WP_252621171.1 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase -
NF557_RS00615 (NF557_00615) 140944..141099 - 156 WP_252621173.1 hypothetical protein -
NF557_RS00620 (NF557_00620) 141184..142332 - 1149 WP_252621174.1 3-hydroxyisobutyryl-CoA hydrolase -
NF557_RS00625 (NF557_00625) 142365..143234 + 870 WP_252621175.1 DUF5926 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-133)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15158.43 Da        Isoelectric Point: 6.3727

>T248944 WP_252621167.1 NZ_CP099490:c138320-137898 [Ornithinimicrobium cryptoxanthini]
VIILDTNVLIYSVHKGASQHERTARWLDRMLAEPQVLGLPWVAALGFIRITTNARIFPEPLTVDEAMTVLDAWHAHPAVT
LPQPTTRHLSVLSGLLREAGTAGNLTTDAHIAALAIEHGASVATFDRDLARFGVTVVVPD

Download         Length: 423 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9261.65 Da        Isoelectric Point: 8.8935

>AT248944 WP_252621168.1 NZ_CP099490:c138580-138323 [Ornithinimicrobium cryptoxanthini]
MRTTITLDPDVTLLIEREMAARNLRFKQVVNEALRRQLGGSQGAPPSLTDFGRDLGVAAVDLTKANQLAAALEDGELLRK
MAQGR

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References