Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 593202..593749 Replicon chromosome
Accession NZ_CP099489
Organism Ornithinimicrobium sp. HY1793

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NF556_RS02740 Protein ID WP_252593974.1
Coordinates 593202..593531 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag NF556_RS02745 Protein ID WP_252593975.1
Coordinates 593528..593749 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF556_RS02710 (NF556_02710) 588235..589530 + 1296 WP_252593968.1 lactate racemase domain-containing protein -
NF556_RS02715 (NF556_02715) 589575..589913 - 339 WP_252593969.1 helix-turn-helix domain-containing protein -
NF556_RS02720 (NF556_02720) 590002..590883 + 882 WP_252593970.1 NAD(P)-binding domain-containing protein -
NF556_RS02725 (NF556_02725) 590955..591392 - 438 WP_252593971.1 nuclear transport factor 2 family protein -
NF556_RS02730 (NF556_02730) 591385..591960 + 576 WP_252593972.1 DapH/DapD/GlmU-related protein -
NF556_RS02735 (NF556_02735) 592035..593168 - 1134 WP_252593973.1 aminotransferase class V-fold PLP-dependent enzyme -
NF556_RS02740 (NF556_02740) 593202..593531 - 330 WP_252593974.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NF556_RS02745 (NF556_02745) 593528..593749 - 222 WP_252593975.1 antitoxin MazE family protein Antitoxin
NF556_RS02750 (NF556_02750) 593814..595730 + 1917 WP_289781773.1 chorismate-binding protein -
NF556_RS02755 (NF556_02755) 595727..596575 + 849 WP_252593976.1 CoA transferase -
NF556_RS02760 (NF556_02760) 596652..598208 + 1557 WP_252593977.1 sodium-dependent transporter -
NF556_RS02765 (NF556_02765) 598205..598360 + 156 WP_252593978.1 MetS family NSS transporter small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-104)

Antitoxin

Antitoxin MazE-like

(6-66)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11936.95 Da        Isoelectric Point: 10.7596

>T248939 WP_252593974.1 NZ_CP099489:c593531-593202 [Ornithinimicrobium sp. HY1793]
VRRGEIFTAAARGPYTGKPRPVVVIQDDRFDATASVTVCPVTTNPVEAPLTRLMIHPTELNGLDQPSRLMVDKVMTMPRT
GLRERVGRLTDGDLVRLNRALIVFLGLAG

Download         Length: 330 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8472.40 Da        Isoelectric Point: 5.6939

>AT248939 WP_252593975.1 NZ_CP099489:c593749-593528 [Ornithinimicrobium sp. HY1793]
MASTQDRVRRHRAKLRRQGLRPVQIWVPDVRAPEFTAEAHRQAAAIAASEMESEDQAFVDAISWEWDEPEQSR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References