Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 708201..709256 | Replicon | chromosome |
| Accession | NZ_CP099471 | ||
| Organism | Roseomonas mucosa strain TT14 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | NF552_RS03445 | Protein ID | WP_252571507.1 |
| Coordinates | 708201..708764 (-) | Length | 188 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | - |
| Locus tag | NF552_RS03450 | Protein ID | WP_252571508.1 |
| Coordinates | 708771..709256 (-) | Length | 162 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NF552_RS03400 (NF552_03400) | 703839..704021 | - | 183 | WP_252571492.1 | hypothetical protein | - |
| NF552_RS03405 (NF552_03405) | 704030..704272 | - | 243 | WP_252571494.1 | hypothetical protein | - |
| NF552_RS03410 (NF552_03410) | 704269..704550 | - | 282 | WP_252571496.1 | hypothetical protein | - |
| NF552_RS03415 (NF552_03415) | 704631..704951 | - | 321 | WP_252571498.1 | hypothetical protein | - |
| NF552_RS03420 (NF552_03420) | 705179..705661 | - | 483 | WP_252571499.1 | hypothetical protein | - |
| NF552_RS03425 (NF552_03425) | 705667..705900 | - | 234 | WP_252571501.1 | hypothetical protein | - |
| NF552_RS03430 (NF552_03430) | 705900..706046 | - | 147 | WP_252571502.1 | hypothetical protein | - |
| NF552_RS03435 (NF552_03435) | 706946..707206 | - | 261 | WP_252571504.1 | hypothetical protein | - |
| NF552_RS03440 (NF552_03440) | 707953..708204 | + | 252 | WP_252571506.1 | hypothetical protein | - |
| NF552_RS03445 (NF552_03445) | 708201..708764 | - | 564 | WP_252571507.1 | PIN domain-containing protein | Toxin |
| NF552_RS03450 (NF552_03450) | 708771..709256 | - | 486 | WP_252571508.1 | helix-turn-helix domain-containing protein | Antitoxin |
| NF552_RS03455 (NF552_03455) | 709524..710765 | - | 1242 | WP_252571509.1 | site-specific integrase | - |
| NF552_RS03460 (NF552_03460) | 711015..711416 | - | 402 | WP_075821692.1 | hypothetical protein | - |
| NF552_RS03465 (NF552_03465) | 711523..712152 | - | 630 | WP_075821691.1 | cysteine hydrolase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 188 a.a. Molecular weight: 21215.40 Da Isoelectric Point: 5.6214
>T248934 WP_252571507.1 NZ_CP099471:c708764-708201 [Roseomonas mucosa]
MAFVALYDACVLYPAPLRDLLLRLARTNLFRARWSEQIHEEWIRGVLRSRPDLHDRLDRTRRMMDQAVDDCLVTGYEALS
PTLSLPDPDDRHVLAAAIVGRADVIVTFNLKDFPAATLSLYGIEAQHPDTFIRHVLDLEEAVAVAAVKQQRASLRNPPKT
VEEFLDILAQQSLPETVTFLRAWSSLI
MAFVALYDACVLYPAPLRDLLLRLARTNLFRARWSEQIHEEWIRGVLRSRPDLHDRLDRTRRMMDQAVDDCLVTGYEALS
PTLSLPDPDDRHVLAAAIVGRADVIVTFNLKDFPAATLSLYGIEAQHPDTFIRHVLDLEEAVAVAAVKQQRASLRNPPKT
VEEFLDILAQQSLPETVTFLRAWSSLI
Download Length: 564 bp
Antitoxin
Download Length: 162 a.a. Molecular weight: 17669.08 Da Isoelectric Point: 6.1038
>AT248934 WP_252571508.1 NZ_CP099471:c709256-708771 [Roseomonas mucosa]
MTLAMPNTTESDLPSEADRQAAKVASRALSRLSGRGCVRVDAVPDSEFSSAAQEGRQTFILPATAVRLLTDMLAHLAEGR
SVTVMPEDAELTTQEAADMLNVSRPHLVKLLQEERIPFHKTGTHRRVALRDLLAYRKARALEANTALDDLAKQAQDLEMG
Y
MTLAMPNTTESDLPSEADRQAAKVASRALSRLSGRGCVRVDAVPDSEFSSAAQEGRQTFILPATAVRLLTDMLAHLAEGR
SVTVMPEDAELTTQEAADMLNVSRPHLVKLLQEERIPFHKTGTHRRVALRDLLAYRKARALEANTALDDLAKQAQDLEMG
Y
Download Length: 486 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|