248929

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 5588501..5589297 Replicon chromosome
Accession NZ_CP099464
Organism Dolichospermum heterosporum TAC447 strain NIES-1697

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag NG743_RS25475 Protein ID WP_257121136.1
Coordinates 5588501..5589010 (-) Length 170 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag NG743_RS25480 Protein ID WP_027401264.1
Coordinates 5589010..5589297 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NG743_RS25440 (NG743_25310) 5584434..5584718 + 285 WP_027401270.1 hypothetical protein -
NG743_RS25445 (NG743_25315) 5584715..5585167 + 453 WP_027401269.1 hypothetical protein -
NG743_RS25450 (NG743_25320) 5585211..5585420 + 210 WP_257121134.1 hypothetical protein -
NG743_RS25455 (NG743_25325) 5585421..5585870 + 450 WP_051424234.1 HNH endonuclease signature motif containing protein -
NG743_RS25460 (NG743_25330) 5586021..5586320 + 300 WP_027401267.1 type II toxin-antitoxin system HigB family toxin -
NG743_RS25465 (NG743_25335) 5586333..5586731 + 399 WP_193964778.1 transcriptional regulator -
NG743_RS25470 (NG743_25340) 5586935..5588230 - 1296 WP_257121135.1 RNA-guided endonuclease IscB -
NG743_RS25475 (NG743_25345) 5588501..5589010 - 510 WP_257121136.1 GNAT family N-acetyltransferase Toxin
NG743_RS25480 (NG743_25350) 5589010..5589297 - 288 WP_027401264.1 DUF1778 domain-containing protein Antitoxin
NG743_RS25485 (NG743_25355) 5589589..5589711 - 123 WP_027400631.1 histone H1 -
NG743_RS25490 (NG743_25360) 5589843..5591318 + 1476 WP_052149947.1 RNA-guided endonuclease TnpB family protein -
NG743_RS25495 (NG743_25365) 5591257..5591457 - 201 WP_257121137.1 aldo/keto reductase -
NG743_RS25500 (NG743_25370) 5591761..5592423 - 663 WP_257121138.1 dienelactone hydrolase family protein -
NG743_RS25505 (NG743_25375) 5592585..5594123 - 1539 WP_257121139.1 amidohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-160)

Antitoxin

Vibrio phage ICP1, Orf50

(12-90)


Sequences

Toxin        


Download         Length: 170 a.a.        Molecular weight: 19299.27 Da        Isoelectric Point: 5.8089

>T248929 WP_257121136.1 NZ_CP099464:c5589010-5588501 [Dolichospermum heterosporum TAC447]
MVLKIELLDSSRHIRTEFCCGKDSLDNYLYKQASQDLKKRVATVFVLIDEPDSHVLAYYTLSAYTVDITVLDEAFAKRLP
RYPYLPATLLGRLAVDNRQKGQGFGELMLVDALKRAFNASRQVGSLAVIAEALDEEVVNFYIKYGFKEFKQNSMKLYIPM
QSVEELVQD

Download         Length: 510 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10407.14 Da        Isoelectric Point: 7.0125

>AT248929 WP_027401264.1 NZ_CP099464:c5589297-5589010 [Dolichospermum heterosporum TAC447]
MDVAPIPKQIARLEARMTPETKALLQKAADLEGRTLTDFVIASVQAEALRVIERHQTLKLSMGDAEAFVDALLNPPQPND
ALKAAALRYKQVITV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References