248926

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4484303..4485090 Replicon chromosome
Accession NZ_CP099464
Organism Dolichospermum heterosporum TAC447 strain NIES-1697

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag NG743_RS20315 Protein ID WP_257120766.1
Coordinates 4484590..4485090 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A0K2LWK8
Locus tag NG743_RS20310 Protein ID WP_053538439.1
Coordinates 4484303..4484593 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NG743_RS20280 (NG743_20180) 4479489..4479944 + 456 WP_027402083.1 50S ribosomal protein L13 -
NG743_RS20285 (NG743_20185) 4479944..4480360 + 417 WP_027402082.1 30S ribosomal protein S9 -
NG743_RS20290 (NG743_20190) 4480470..4480712 + 243 WP_027402081.1 50S ribosomal protein L31 -
NG743_RS20295 (NG743_20195) 4480834..4481934 + 1101 WP_027402080.1 peptide chain release factor 1 -
NG743_RS20300 (NG743_20200) 4482070..4482570 - 501 WP_027402079.1 2TM domain-containing protein -
NG743_RS20305 (NG743_20205) 4482983..4483882 - 900 WP_027402078.1 M48 family metallopeptidase -
NG743_RS20310 (NG743_20210) 4484303..4484593 + 291 WP_053538439.1 DUF1778 domain-containing protein Antitoxin
NG743_RS20315 (NG743_20215) 4484590..4485090 + 501 WP_257120766.1 GNAT family N-acetyltransferase Toxin
NG743_RS20320 (NG743_20220) 4485165..4486883 - 1719 WP_257120767.1 ABC transporter ATP-binding protein -
NG743_RS20325 (NG743_20225) 4487011..4487634 - 624 WP_027402073.1 exopolysaccharide biosynthesis protein -
NG743_RS20330 (NG743_20230) 4487674..4487811 - 138 WP_257120768.1 hypothetical protein -
NG743_RS20335 (NG743_20235) 4487906..4488688 + 783 WP_257120769.1 ABC transporter permease -
NG743_RS20340 (NG743_20240) 4488789..4489508 - 720 WP_257120770.1 Uma2 family endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(24-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18114.89 Da        Isoelectric Point: 7.2134

>T248926 WP_257120766.1 NZ_CP099464:4484590-4485090 [Dolichospermum heterosporum TAC447]
MSLTPPETLSSHHSCSDFSCGIASLDDWLKRRAYTNQISGATRTFVLCVDNRIVGYYALASGAISVQSALGKFRRNMPDP
IPVVILARLAIDSSYQSQGLGRALFRDAALRVVQAADTIGIRGIIVHAISEEAKDFYLALGFILSPLEPMTLMISLNDLR
DSIPEK

Download         Length: 501 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11024.67 Da        Isoelectric Point: 8.5952

>AT248926 WP_053538439.1 NZ_CP099464:4484303-4484593 [Dolichospermum heterosporum TAC447]
MTNKTKNITVRNTLNLRIKPEERDLIDMAAKVLGKNRTDFILAAARNAAEETLLERTIFWASPEAYAEFIALLDAPPQPN
ERLRKTMQTTPPWDKE

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2LWK8

References