248924

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4091831..4092234 Replicon chromosome
Accession NZ_CP099464
Organism Dolichospermum heterosporum TAC447 strain NIES-1697

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NG743_RS18320 Protein ID WP_096666998.1
Coordinates 4091831..4092022 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1Z4V340
Locus tag NG743_RS18325 Protein ID WP_027402154.1
Coordinates 4092022..4092234 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NG743_RS18295 (NG743_18200) 4086891..4087793 - 903 WP_027402148.1 cation diffusion facilitator family transporter -
NG743_RS18300 (NG743_18205) 4088066..4088413 + 348 WP_027402149.1 hypothetical protein -
NG743_RS18305 (NG743_18210) 4088706..4088906 + 201 Protein_3619 ISKra4 family transposase -
NG743_RS18310 (NG743_18215) 4088991..4089515 + 525 WP_257120627.1 hypothetical protein -
NG743_RS18315 (NG743_18220) 4089572..4091521 + 1950 WP_257120628.1 TaqI-like C-terminal specificity domain-containing protein -
NG743_RS18320 (NG743_18225) 4091831..4092022 + 192 WP_096666998.1 type II toxin-antitoxin system HicA family toxin Toxin
NG743_RS18325 (NG743_18230) 4092022..4092234 + 213 WP_027402154.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NG743_RS18330 (NG743_18235) 4092384..4092938 + 555 WP_257120630.1 Uma2 family endonuclease -
NG743_RS18335 (NG743_18240) 4093207..4094421 + 1215 WP_027402156.1 FIST N-terminal domain-containing protein -
NG743_RS18340 (NG743_18245) 4094634..4095737 - 1104 WP_027402157.1 metallophosphoesterase -
NG743_RS18345 (NG743_18250) 4095886..4096590 + 705 WP_051424288.1 tRNA (guanosine(46)-N7)-methyltransferase TrmB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7197.34 Da        Isoelectric Point: 10.5626

>T248924 WP_096666998.1 NZ_CP099464:4091831-4092022 [Dolichospermum heterosporum TAC447]
MKVRAVIQRLEADGWYLARTRGSHRQFKHPDKLGIVTVSGKPNIDVPIGTLKSIWKQAQLEEE

Download         Length: 192 bp

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7599.79 Da        Isoelectric Point: 3.7890

>AT248924 WP_027402154.1 NZ_CP099464:4092022-4092234 [Dolichospermum heterosporum TAC447]
MRYTVVIEKGNSSYGAYVPDLPGCIAVAETLVEVQQMIVEAIEFHIEGLIESGLPIPQPTSIAQEVEVLI

Download         Length: 213 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z4V340

References