248923

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3854490..3855058 Replicon chromosome
Accession NZ_CP099464
Organism Dolichospermum heterosporum TAC447 strain NIES-1697

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NG743_RS17200 Protein ID WP_039201266.1
Coordinates 3854490..3854825 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1Z4V8H8
Locus tag NG743_RS17205 Protein ID WP_027402546.1
Coordinates 3854819..3855058 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NG743_RS17180 (NG743_17090) 3849938..3850777 - 840 WP_027402547.1 DUF2887 domain-containing protein -
NG743_RS17185 (NG743_17095) 3850868..3851095 - 228 WP_152608969.1 hypothetical protein -
NG743_RS17190 (NG743_17100) 3851608..3852453 - 846 WP_257120532.1 DUF2887 domain-containing protein -
NG743_RS17195 (NG743_17105) 3852710..3853627 - 918 WP_257120533.1 DUF2887 domain-containing protein -
NG743_RS17200 (NG743_17110) 3854490..3854825 - 336 WP_039201266.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NG743_RS17205 (NG743_17115) 3854819..3855058 - 240 WP_027402546.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NG743_RS17210 (NG743_17120) 3855738..3856000 - 263 Protein_3402 hypothetical protein -
NG743_RS17215 (NG743_17125) 3856142..3856609 - 468 WP_027402545.1 DUF29 domain-containing protein -
NG743_RS17220 (NG743_17130) 3857900..3858808 - 909 WP_193964719.1 DUF4351 domain-containing protein -
NG743_RS17225 (NG743_17135) 3859015..3859161 - 147 WP_152540446.1 SAF domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12948.08 Da        Isoelectric Point: 7.7001

>T248923 WP_039201266.1 NZ_CP099464:c3854825-3854490 [Dolichospermum heterosporum TAC447]
MVDYVPRYGDLVWLNFDPQSGHEQMGQRPALVLSHTEFNQQRGFIFVCPISNTKRKNPFYVEIPDDQPIKGVVMCDQLRS
LDYRSRKAKLICICPEWLLAEVLGRIHPILF

Download         Length: 336 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9088.34 Da        Isoelectric Point: 4.4012

>AT248923 WP_027402546.1 NZ_CP099464:c3855058-3854819 [Dolichospermum heterosporum TAC447]
MKSQIGRWGNSLALRIPKYIADELALSINDEVDCRIEQGQLMVRPVQKFPKYTLSQLLSQDLEPEAEIDWGKPTGNEEW

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z4V8H8

References