248914

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 1376970..1377797 Replicon chromosome
Accession NZ_CP099464
Organism Dolichospermum heterosporum TAC447 strain NIES-1697

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag NG743_RS06115 Protein ID WP_257121705.1
Coordinates 1377225..1377797 (+) Length 191 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag NG743_RS06110 Protein ID WP_257121704.1
Coordinates 1376970..1377224 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NG743_RS06090 (NG743_06070) 1373375..1374334 - 960 WP_193965010.1 IS110 family transposase -
NG743_RS06095 (NG743_06075) 1374716..1375018 + 303 WP_257121702.1 type II toxin-antitoxin system PrlF family antitoxin -
NG743_RS06100 (NG743_06080) 1375015..1375488 + 474 WP_257121703.1 type II toxin-antitoxin system YhaV family toxin -
NG743_RS06105 (NG743_06085) 1375689..1376909 + 1221 WP_027400610.1 ISL3 family transposase -
NG743_RS06110 (NG743_06090) 1376970..1377224 + 255 WP_257121704.1 helix-turn-helix domain-containing protein Antitoxin
NG743_RS06115 (NG743_06095) 1377225..1377797 + 573 WP_257121705.1 PIN domain-containing protein Toxin
NG743_RS06120 (NG743_06100) 1377924..1378205 + 282 WP_027404402.1 antibiotic biosynthesis monooxygenase -
NG743_RS06125 (NG743_06105) 1378230..1380371 - 2142 WP_257121706.1 serine/threonine-protein kinase -
NG743_RS06130 (NG743_06110) 1380921..1381337 + 417 WP_257121707.1 helix-turn-helix domain-containing protein -
NG743_RS06135 (NG743_06115) 1381401..1382012 + 612 WP_257120845.1 IS607 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1375689..1376909 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-115)

Antitoxin

SinI-like, DNA-binding domain

(14-59)


Sequences

Toxin        


Download         Length: 191 a.a.        Molecular weight: 21954.63 Da        Isoelectric Point: 5.0559

>T248914 WP_257121705.1 NZ_CP099464:1377225-1377797 [Dolichospermum heterosporum TAC447]
MQAIGLIVVYDACVLYPAPLRDFLMWLALTDLFQAKWTEKIHEEWMNYVLKNRPDLTYKQLERTKKLMNQNVRDCLVTGY
EQLIDELELPDADDRHVLAAAIKSDAEIIVTFNLKDFLSENIGQYGIKAQHPDEFILHLINLNSDLVCQAVKNQLNTLKK
PPINLDELLEILIKQQIPKSVSVLQKLLIN

Download         Length: 573 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9710.09 Da        Isoelectric Point: 9.5031

>AT248914 WP_257121704.1 NZ_CP099464:1376970-1377224 [Dolichospermum heterosporum TAC447]
MQTRKANLATFDQITTQKAAKILNVSHPYLIQLLDSGEIPCHKVGNRRRIFYQDLTEYKNTIDAKRRETLAELANQAQEL
NMGY

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References