248911

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1240986..1241903 Replicon chromosome
Accession NZ_CP099460
Organism Bacillus velezensis strain E

Toxin (Protein)


Gene name spoIISA Uniprot ID I2HQ15
Locus tag NF199_RS06515 Protein ID WP_007407256.1
Coordinates 1241157..1241903 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag NF199_RS06510 Protein ID WP_003154807.1
Coordinates 1240986..1241156 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NF199_RS06470 1236222..1237841 + 1620 WP_265606232.1 pyocin knob domain-containing protein -
NF199_RS06475 1237854..1238225 + 372 WP_032874603.1 XkdW family protein -
NF199_RS06480 1238230..1238427 + 198 WP_032874605.1 XkdX family protein -
NF199_RS06485 1238484..1239245 + 762 WP_032874607.1 hypothetical protein -
NF199_RS06490 1239297..1239560 + 264 WP_003154815.1 hemolysin XhlA family protein -
NF199_RS06495 1239574..1239837 + 264 WP_003154813.1 phage holin -
NF199_RS06500 1239851..1240729 + 879 WP_032874609.1 N-acetylmuramoyl-L-alanine amidase -
NF199_RS06505 1240764..1240889 - 126 WP_003154809.1 hypothetical protein -
NF199_RS06510 1240986..1241156 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
NF199_RS06515 1241157..1241903 - 747 WP_007407256.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
NF199_RS06520 1242008..1243006 - 999 WP_032874611.1 inorganic phosphate transporter -
NF199_RS06525 1243019..1243636 - 618 WP_032874614.1 DUF47 domain-containing protein -
NF199_RS06530 1243924..1245237 - 1314 Protein_1225 amino acid permease -
NF199_RS06535 1245559..1246509 + 951 WP_032874618.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29077.57 Da        Isoelectric Point: 4.7755

>T248911 WP_007407256.1 NZ_CP099460:c1241903-1241157 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT248911 WP_003154807.1 NZ_CP099460:c1241156-1240986 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2HQ15

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References