Detailed information of TA system TA024891

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 587253..588031
• Replicon: chromosome
• Accession: NC_014500
• Organism: Dickeya dadantii 3937

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: DDA3937_RS02650
• Protein ID: WP_033111579.1
• Coordinates: 587543..588031 (+)
• Length: 163 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: E0SK16
• Locus tag: DDA3937_RS02645
• Protein ID: WP_013316243.1
• Coordinates: 587253..587546 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DDA3937_RS02630 (Dda3937_02702)	582713..584452	+	1740	WP_013316238.1	TIGR04141 family sporadically distributed protein	-
DDA3937_RS21825	584740..585034	-	295	Protein_522	type II toxin-antitoxin system toxin CcdB	-
DDA3937_RS22990	585046..585147	-	102	Protein_523	type II toxin-antitoxin system CcdA family antitoxin	-
DDA3937_RS02640 (Dda3937_02703)	585621..586112	-	492	WP_033111578.1	hypothetical protein	-
DDA3937_RS02645 (Dda3937_02704)	587253..587546	+	294	WP_013316243.1	DUF1778 domain-containing protein	Antitoxin
DDA3937_RS02650 (Dda3937_02705)	587543..588031	+	489	WP_033111579.1	GNAT family N-acetyltransferase	Toxin
DDA3937_RS02655 (Dda3937_02706)	588528..590570	-	2043	WP_013316245.1	RNA-directed DNA polymerase	-
DDA3937_RS02660 (Dda3937_02707)	590563..591906	-	1344	WP_013316246.1	RNA-directed DNA polymerase	-
DDA3937_RS02665 (Dda3937_02708)	592071..592376	-	306	WP_013316247.1	type II toxin-antitoxin system toxin CcdB	-
DDA3937_RS02670 (Dda3937_02709)	592379..592597	-	219	WP_012773205.1	type II toxin-antitoxin system antitoxin CcdA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	586837..596539	9702

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (44-143)

Antitoxin

• Vibrio phage ICP1, Orf50 (14-88)

Sequences

Toxin

Protein

• Length: 163 a.a.
• Molecular weight: 17501.39 Da
• Isoelectric Point: 7.7788

>T24891 WP_033111579.1 NC_014500:587543-588031 [Dickeya dadantii 3937]
MISAPEPLRAEHVLSSFCCGVESMDNWLKLRAMKNQVTGASRTFVSCDDSKVLAYYSLASSAVATNAAPGRFRRNMPDPI
PIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVADTIGIRGMLVHALSDEAREFYLRVGFEPSPIDPMMLMVTLGDLVG
SI

Nucleotide

• Length: 489 bp

>T24891 NC_014500:587543-588031 [Dickeya dadantii 3937]
ATGATATCCGCCCCTGAGCCACTTCGCGCCGAACATGTACTTTCCTCGTTCTGTTGCGGCGTGGAGTCTATGGACAACTG
GCTAAAACTACGGGCGATGAAAAATCAGGTCACTGGAGCATCACGAACTTTCGTCAGTTGCGATGATTCAAAAGTGTTAG
CGTATTACTCATTGGCTTCCAGCGCCGTGGCAACGAATGCCGCTCCTGGACGCTTTCGCCGCAATATGCCCGATCCAATT
CCGATCGTGGTGCTGGGGCGTCTGGCGGTAGATAAATCATTACATGGTCAGGGCGTTGGCCGGGCGCTGGTGCGTGATGC
CGGGCTACGGGTGATTCAGGTGGCGGATACCATAGGTATTCGCGGGATGTTGGTTCATGCTCTGTCTGATGAAGCGCGGG
AATTTTACCTACGAGTTGGGTTTGAGCCTTCCCCAATTGACCCGATGATGCTGATGGTGACGTTGGGGGATTTGGTGGGG
AGTATTTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10885.57 Da
• Isoelectric Point: 10.1968

>AT24891 WP_013316243.1 NC_014500:587253-587546 [Dickeya dadantii 3937]
MPVTNSVSVKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIDQRIIMADPDAYQEFLARLDQAPAPN
AALRKTMQTLAPWELKK

Nucleotide

• Length: 294 bp

>AT24891 NC_014500:587253-587546 [Dickeya dadantii 3937]
ATGCCAGTGACGAATAGTGTTTCTGTTAAACGCGAAACATTGAATTTACGCATCAAGCCCGCTGAACGCGATCTGATCGA
TCGTGCAGCGAAGGCCAGAGGAAAAAATCGCACTGATTTTGTTCTTGAGGCTGCCCGCGCCGCCGCAGAGGAAGCGTTGA
TCGATCAGCGCATCATCATGGCAGATCCCGATGCTTATCAGGAATTCCTTGCCCGTTTAGATCAGGCTCCTGCACCAAAT
GCTGCGCTGCGAAAAACCATGCAAACTCTTGCACCGTGGGAATTGAAAAAATGA

Structures

Antitoxin

• AlphaFold DB: E0SK16